Evidence map›Paper›PMID 35011003›Full record

ArticleNutrients2021

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.

Karen E Christensen, Olga V Malysheva, Stephanie Carlin, Fernando Matias, Amanda J MacFarlane, René L Jacobs, Marie A Caudill, Rima Rozen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. A novelFrontiers in genetics · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karen E ChristensenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0003-1741-0375
Olga V MalyshevaDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Stephanie CarlinDivision of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Fernando MatiasNutrition Research Division, Health Canada, Ottawa, ON K1A 0K9, Canada.
Amanda J MacFarlaneNutrition Research Division, Health Canada, Ottawa, ON K1A 0K9, Canada.
René L JacobsDivision of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.ORCID 0000-0002-5525-1355
Marie A CaudillDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-7192-5743
Rima RozenDepartments of Human Genetics and Pediatrics, McGill University, Montreal, QC H3A 0C7, Canada.

Funding

CIHR PJT-156389Natural Sciences and Engineering Research Council RES 25104
6 · The paper itself

Abstract

Folate and choline are interconnected metabolically. The MTHFD1 R653Q SNP is a risk factor for birth defects and there are concerns that choline deficiency may interact with this SNP and exacerbate health risks. 80-90% of women do not meet the Adequate Intake (AI) for choline. The objective of this study was to assess the effects of choline deficiency on maternal one-carbon metabolism and reproductive outcomes in the MTHFD1-synthetase deficient mouse (

Indexed as

AminohydrolasesAnimalsCholineCholine DeficiencyDevelopmental DisabilitiesDisease Models, AnimalEmbryonic DevelopmentFemaleFolic AcidFormate-Tetrahydrofolate LigaseGenotypeIncidenceLiverMaternal Nutritional Physiological PhenomenaMethenyltetrahydrofolate CyclohydrolaseMethylenetetrahydrofolate Dehydrogenase (NADP)AminohydrolasesCholineFolic AcidFormate-Tetrahydrofolate Ligaseformyl-methenyl-methylenetetrahydrofolate synthetaseMethenyltetrahydrofolate CyclohydrolaseMethylenetetrahydrofolate Dehydrogenase (NADP)Mthfd1 protein, mouseMultienzyme ComplexesMultifunctional Enzymesbirth defectscholinedevelopmental defectsdevelopmental delayembryonic developmentfolateMTHFD1

Identifiers

PMID35011003
PMCPMC8747146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.