Evidence map›Paper›PMID 35010991›Full record

ArticleNutrients2021

Roux-en-Y Gastric Bypass and Caloric Restriction but Not Gut Hormone-Based Treatments Profoundly Impact the Hypothalamic Transcriptome in Obese Rats.

Ulrich Dischinger, Tobias Heckel, Thorsten Bischler, Julia Hasinger, Malina Königsrainer, Angelika Schmitt-Böhrer, Christoph Otto, Martin Fassnacht, Florian Seyfried, Mohammed Khair Hankir

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In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. The Mechanism of Leptin Resistance in Obesity and Therapeutic Perspective.Advances in experimental medicine and biology · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ulrich DischingerDepartment of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.
Tobias HeckelCore Unit Systems Medicine, University of Wurzburg, 97080 Wurzburg, Germany.
Thorsten BischlerCore Unit Systems Medicine, University of Wurzburg, 97080 Wurzburg, Germany.ORCID 0000-0001-9288-9481
Julia HasingerDepartment of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.
Malina KönigsrainerDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.
Angelika Schmitt-BöhrerDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.
Christoph OttoDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.
Martin FassnachtDepartment of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.ORCID 0000-0001-6170-6398
Florian SeyfriedDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.ORCID 0000-0002-5915-8692
Mohammed Khair HankirDepartment of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital, University of Wurzburg, 97080 Wurzburg, Germany.

Funding

IZKF Würzburg, Germany Z-2/71 and Z-6
6 · The paper itself

Abstract

backgroundThe hypothalamus is an important brain region for the regulation of energy balance. Roux-en-Y gastric bypass (RYGB) surgery and gut hormone-based treatments are known to reduce body weight, but their effects on hypothalamic gene expression and signaling pathways are poorly studied.

methodsDiet-induced obese male Wistar rats were randomized into the following groups: RYGB, sham operation, sham + body weight-matched (BWM) to the RYGB group, osmotic minipump delivering PYY3-36 (0.1 mg/kg/day), liraglutide s.c. (0.4 mg/kg/day), PYY3-36 + liraglutide, and saline. All groups (except BWM) were kept on a free choice of high- and low-fat diets. Four weeks after interventions, hypothalami were collected for RNA sequencing.

resultsWhile rats in the RYGB, BWM, and PYY3-36 + liraglutide groups had comparable reductions in body weight, only RYGB and BWM treatment had a major impact on hypothalamic gene expression. In these groups, hypothalamic leptin receptor expression as well as the JAK-STAT, PI3K-Akt, and AMPK signaling pathways were upregulated. No significant changes could be detected in PYY3-36 + liraglutide-, liraglutide-, and PYY-treated groups.

conclusionsDespite causing similar body weight changes compared to RYGB and BWM, PYY3-36 + liraglutide treatment does not impact hypothalamic gene expression. Whether this striking difference is favorable or unfavorable to metabolic health in the long term requires further investigation.

Indexed as

AnimalsBody WeightCaloric RestrictionDisease Models, AnimalEnergy MetabolismGastric BypassGastrointestinal HormonesGene ExpressionHypothalamusLiraglutideMaleObesityPeptide FragmentsPeptide YYRatsRats, WistarGastrointestinal HormonesLiraglutidePeptide FragmentsPeptide YYpeptide YY (3-36)hypothalamic gene expressionliraglutideobesityPYY3-36Roux-en-Y gastric bypass surgery

Identifiers

PMID35010991
PMCPMC8746874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.