ReviewNutrients2021
The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses.Nutrition & diabetes · 2024Pooled it
- Pooled it
- Vitamin/mineral/micronutrient supplement for autism spectrum disorders: a research survey.BMC pediatrics · 2022Trial
- Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq.World journal of clinical pediatrics · 2026Article
- Co-exposure to lead and cadmium is associated with increased severity of social deficits in children with autism spectrum disorders.Frontiers in nutrition · 2026Article
- High-Fat Diet Exacerbates Behavioral and Neurochemical Deficits in BTBR Mice: Linking Intestinal Inflammation and Brain Neurotransmitter Dysregulation to Melatonin Therapeutic Potential.Molecular neurobiology · 2025Article
- Occurrence and Correlates of Vitamin D and Iron Deficiency in Children with Autism Spectrum Disorder.Nutrients · 2025Observational
- Vitamin D in Disease Prevention and Cure-Part I: An Update on Molecular Mechanism and Significance on Human Health.Indian journal of clinical biochemistry : IJCB · 2025Review
- Nutritional management and autism spectrum disorder: A systematic review.World journal of clinical pediatrics · 2024Article
- Nutritional Status and Dietary Behaviors of Children with Intellectual or Developmental Disabilities in Saudi Arabia: A Systematic Review.Journal of multidisciplinary healthcare · 2024Review
- The role of vitamin D deficiency in the development of paediatric diseases.Annals of medicine · 2023Review
- Benefits of Vitamin D in Health and Diseases.Nutrients · 2023Article
- The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder.Journal of personalized medicine · 2023Review
- The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders.Neuropsychiatric disease and treatment · 2023Review
- Dietary Supplements among Children Ages 0-3 Years in Poland-Are They Necessary?Foods (Basel, Switzerland) · 2022Article
- GC1f Vitamin D Binding Protein Isoform as a Marker of Severity in Autism Spectrum Disorders.Nutrients · 2022Article
- A Personalized Multidisciplinary Approach to Evaluating and Treating Autism Spectrum Disorder.Journal of personalized medicine · 2022Review
- Diet and special educational needs (SENs) among children and adolescents: a systematic review.Porto biomedical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with autism spectrum disorder (ASD) present with persistent deficits in both social communication and interactions, along with the presence of restricted and repetitive behaviors, resulting in significant impairment in significant areas of functioning. Children with ASD consistently reported significantly lower vitamin D levels than typically developing children. Moreover, vitamin D deficiency was found to be strongly correlated with ASD severity. Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels. A Title/Abstract specific search for publications on Vitamin D supplementation trials up to June 2021 was performed using two databases: PubMed and Cochrane Library. Twelve experimental studies were included in the synthesis of this review. Children with ASD reported a high prevalence of vitamin D deficiency or insufficiency. In general, it was observed that improved vitamin D status significantly reduced the ASD severity, however, this effect was not consistently different between the treatment and control groups. The variations in vitamin D dose protocols and the presence of concurrent interventions might provide an explanation for the variability of results. The age of the child for introducing vitamin D intervention was identified as a possible factor determining the effectiveness of the treatment. Common limitations included a small number of participants and a short duration of follow-ups in the selected studies. Long-term, well-designed randomized controlled trials are warranted to confirm the effect of vitamin D on severity in children with ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.