Evidence map›Paper›PMID 35010710›Full record

ArticleInternational journal of environmental research and public health2021

Investigating Potential Dose-Response Relationships between Vitamin D Status and Cognitive Performance: A Cross-Sectional Analysis in Middle- to Older-Aged Adults in the Busselton Healthy Ageing Study.

Janis D Harse, Kun Zhu, Romola S Bucks, Michael Hunter, Ee Mun Lim, Brian R Cooke, John P Walsh, Kevin Murray

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Janis D HarseSchool of Population and Global Health, University of Western Australia, Perth 6009, Australia.
Kun ZhuDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth 6009, Australia.
Romola S BucksSchool of Psychological Science, University of Western Australia, Perth 6009, Australia.
Michael HunterSchool of Population and Global Health, University of Western Australia, Perth 6009, Australia.
Ee Mun LimDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth 6009, Australia.
Brian R CookePathWest Laboratory Medicine, Department of Clinical Biochemistry, Fiona Stanley Hospital, Perth 6150, Australia.
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth 6009, Australia.
Kevin MurraySchool of Population and Global Health, University of Western Australia, Perth 6009, Australia.ORCID 0000-0002-8856-6046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low vitamin D status has been linked to adverse cognitive outcomes in older adults. However, relationships at higher levels remain uncertain. We aimed to clarify patterns of association between vitamin D status and cognitive performance, using flexible regression methods, in 4872 middle- to older-aged adults (2678 females) from the Busselton Healthy Ageing Study. Cross-sectional associations of serum levels of 25-hydroxyvitamin D (25OHD) and performance in cognitive domains were modelled using linear regression and restricted cubic splines, controlling for demographic, lifestyle, and health factors. Mean ± SD serum 25OHD levels were 78 ± 24 nM/L for women and 85 ± 25 nM/L for men. Increasing levels in women were associated with better global cognition (linear trend,

Indexed as

Healthy AgingVitamin D DeficiencyAgedCognitionCross-Sectional StudiesFemaleHumansMaleMiddle AgedVitamin DVitaminsVitamin DVitamins25-hydroxyvitamin Dcognitive ageingcognitive performancedomain-specific cognitionglobal cognitionvitamin D

Identifiers

PMID35010710
PMCPMC8744852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.