Evidence map›Paper›PMID 35010571›Full record

ArticleInternational journal of environmental research and public health2021

TUBE Project: Transport-Derived Ultrafines and the Brain Effects.

Maria-Viola Martikainen, Päivi Aakko-Saksa, Lenie van den Broek, Flemming R Cassee, Roxana O Carare, Sweelin Chew, Andras Dinnyes, Rosalba Giugno, Katja M Kanninen, Tarja Malm and 14 more

Registry-linked trialAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07237958 (Effects on the Olfactory Epithelium in the Nose and the Olfactory Nerve), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07237958 nacompletednot on this map

Effects on the Olfactory Epithelium in the Nose and the Olfactory Nerve (Nervus Olfactorius) From Exposure to Diesel Exhaust

TypeinterventionalSponsorUmeå UniversityRan2019 to 2023Enrolled40ConditionsAlzheimer Disease (AD), Dementia Alzheimer Type, Air Pollution ExposureArmsDiesel Exhaust Particles, Filtered air
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Maria-Viola MartikainenDepartment of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland.ORCID 0000-0001-9541-5871
Päivi Aakko-SaksaVTT Technical Research Centre of Finland Ltd., 02044 Espoo, Finland.ORCID 0000-0003-2995-0889
Lenie van den BroekMimetas BV, 2312 BZ Oegstgeest, The Netherlands.
Flemming R CasseeCentre for Sustainability, Environment and Health, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands.
Roxana O CarareFaculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
Sweelin ChewA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Andras DinnyesBiotalentum Ltd., 2100 Godollo, Hungary.ORCID 0000-0003-3791-2583
Rosalba GiugnoComputer Science Department, University of Verona, 37129 Verona, Italy.ORCID 0000-0001-9843-7638
Katja M KanninenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Tarja MalmA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Ala MualaDepartment of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden.
Maiken NedergaardCenter for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Anna OudinDepartment of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden.
Pedro OyolaCentro Mario Molina Chile, Strategic Studies Department, Santiago 602, Chile.
Tobias V PfeifferVSParticle B.V., 2629 JD Delft, The Netherlands.
Topi RönkköAerosol Physics Laboratory, Physics Unit, Faculty of Engineering and Natural Sciences, Tampere University, 33720 Tampere, Finland.
Sanna SaarikoskiAtmospheric Composition Research, Finnish Meteorological Institute, 00101 Helsinki, Finland.
Thomas SandströmDepartment of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden.
Roel P F SchinsIUF-Leibniz Research Institute for Environmental Medicine, 40225 Dusseldorf, Germany.ORCID 0000-0001-5881-6289
Jan TopinkaDepartment of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the CAS, Videnska 1083, 142 20 Prague, Czech Republic.
Mo YangDepartment of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland.
Xiaowen ZengGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Remco H S WesterinkInstitute for Risk Assessment Sciences (IRAS), Utrecht University, 3508 TD Utrecht, The Netherlands.ORCID 0000-0003-4948-2007
Pasi I JalavaDepartment of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland.

Funding

Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8M
Age and AD related bottlenecks in glymphatic-lymphatic waste transportRF1AG057575 · NIA · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2017 to 2017
$3.2M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
Capillary hyperemia in white matter: Novel mechanistic insight and effect of hypertension and agingRF1NS110049 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN, WAN, JIANDI · 2018 to 2018
$2.9M
NCCIH NIH HHS R01 AT011439NIA NIH HHS RF1 AG057575NINDS NIH HHS R01 NS100366NINDS NIH HHS RF1 NS110049
6 · The paper itself

Abstract

The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer's disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.

Indexed as

Air PollutantsAir PollutionBrainParticle SizeParticulate MatterAir PollutantsParticulate Matterair pollutionbrainCNSparticulate mattertoxicologytrafficUFP

Identifiers

PMID35010571
PMCPMC8751045

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.