Evidence map›Paper›PMID 35009966›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole.

Irina A Shurygina, Galina F Prozorova, Irina S Trukhan, Svetlana A Korzhova, Nataliya N Dremina, Artem I Emel'yanov, Olesya V Say, Nadezhda P Kuznetsova, Alexander S Pozdnyakov, Michael G Shurygin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Irina A ShuryginaIrkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.ORCID 0000-0003-3980-050X
Galina F ProzorovaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Irina S TrukhanIrkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.ORCID 0000-0002-0270-404X
Svetlana A KorzhovaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Nataliya N DreminaIrkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.ORCID 0000-0002-2540-4525
Artem I Emel'yanovA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.ORCID 0000-0001-5025-5843
Olesya V SayIrkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.
Nadezhda P KuznetsovaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.
Alexander S PozdnyakovA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Street, 664033 Irkutsk, Russia.ORCID 0000-0002-9365-3697
Michael G ShuryginIrkutsk Scientific Center of Surgery and Traumatology, 1 Bortsov Revolutsii Street, 664003 Irkutsk, Russia.ORCID 0000-0001-5921-0318

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium. The synthesized new water-soluble copper-containing nanocomposite is promising for biotechnological and biomedical research as a new non-toxic hydrophilic preparation that is allowed to regulate the work of key enzymes involved in energy metabolism and antioxidant protection as well as potentially serving as an additional source of copper.

Indexed as

copper-dependent enzyme systemscopper nanocompositecytotoxicityhepatocytepoly-N-vinylimidazole

Identifiers

PMID35009966
PMCPMC8746882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.