CMOS-Based Redox-Type Label-Free ATP Image Sensor for In Vitro Sensitive Imaging of Extracellular ATP.

Hideo Doi, Tomoko Horio, Yong-Joon Choi, Kazuhiro Takahashi, Toshihiko Noda, Kazuaki Sawada

Open access · goldAbstract read

In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Surface-modified CMOS biosensors.Frontiers in bioengineering and biotechnology · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hideo DoiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.ORCID 0000-0001-8525-8809

Tomoko HorioDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.

Yong-Joon ChoiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.ORCID 0000-0003-1063-3752

Kazuhiro TakahashiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.

Toshihiko NodaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.

Kazuaki SawadaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan.

Toyohashi University of Technology · JP

Funding

Japan Society for the Promotion of Science 20J11860JST CREST JPMJCR14G2JST OPERA JPMJOP 1834

6 · The paper itself

Abstract

Adenosine 5'-triphosphate (ATP) plays a crucial role as an extracellular signaling molecule in the central nervous system and is closely related to various nerve diseases. Therefore, label-free imaging of extracellular ATP dynamics and spatiotemporal analysis is crucial for understanding brain function. To decrease the limit of detection (LOD) of imaging extracellular ATP, we fabricated a redox-type label-free ATP image sensor by immobilizing glycerol-kinase (GK), L-α-glycerophosphate oxidase (LGOx), and horseradish peroxidase (HRP) enzymes in a polymer film on a gold electrode-modified potentiometric sensor array with a 37.3 µm-pitch. Hydrogen peroxide (H

Indexed as

Biosensing TechniquesHydrogen PeroxideAdenosine TriphosphateEnzymes, ImmobilizedHorseradish PeroxidaseOxidation-ReductionAdenosine TriphosphateEnzymes, ImmobilizedHorseradish PeroxidaseHydrogen Peroxideadenosine triphosphatebio-imaginglabel-free detectionpotentiometric sensor arrayredox-enzyme

Identifiers

PMID35009624

DOI10.3390/s22010075

PMCPMC8747181

OpenAlexW4200267495

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.