ReviewMaterials (Basel, Switzerland)2021
A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery.
Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Use of open-source software and photogrammetry in the fabrication of 3D-printed custom trays for edentulous patients: A technical guide.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026Article
- Review
- Simple rigid skull base reconstruction with resorbable unsintered hydroxyapatite/poly-l-lactide plate in endoscopic endonasal skull base tumor surgery: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Evaluation of postoperative stability of the mandibular midline widening osteotomy technique with concurrent genioplasty for correction of bimaxillary transverse discrepancy.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Delayed inflammation after biodegradable and osteoconductive osteofixation in orthognathic surgery.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- ZnInternational journal of molecular sciences · 2024Article
- Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.Advanced healthcare materials · 2024Review
- Article
- Tongue-in-Groove: A Novel Implant Design for a Blow-Out Fracture.Journal of clinical medicine · 2024Article
- Balancing beauty and science: a review of facial implant materials in craniofacial surgery.Frontiers in surgery · 2024Review
- In Vivo Evaluation of Bone Regenerative Capacity of the Novel Nanobiomaterial: β-Tricalcium Phosphate Polylactic Acid-co-Glycolide (β-TCP/PLLA/PGA) for Use in Maxillofacial Bone Defects.Nanomaterials (Basel, Switzerland) · 2023Article
- Article
- Co-culture bioprinting of tissue-engineered bone-periosteum biphasic complex for repairing critical-sized skull defects in rabbits.International journal of bioprinting · 2023Article
- Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance.Pharmaceutics · 2022Review
- Article
- Rigid versus Resorbable Plate Fixation in Fronto-Orbital Advancement in Unicoronal Stenosis - A Retrospective Study.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of bioresorbable materials to overcome limitations and replace traditional bone-reconstruction titanium-plate systems for bone fixation, thus achieving greater efficiency and safety in medical and dental applications, has ushered in a new era in biomaterial development. Because of its bioactive osteoconductive ability and biocompatibility, the forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted considerable interest from researchers in bone tissue engineering, as well as from clinicians, particularly for applications in maxillofacial reconstructive surgery. Thus, various in vitro studies, in vivo studies, and clinical trials have been conducted to investigate the feasibility and weaknesses of this biomaterial in oral and maxillofacial surgery. Various technical improvements have been proposed to optimize its advantages and limit its disadvantages. This narrative review presents an up-to-date, comprehensive review of u-HA/PLLA, a bioactive osteoconductive and bioresorbable bone-reconstruction and -fixation material, in the context of oral and maxillofacial surgery, notably maxillofacial trauma, orthognathic surgery, and maxillofacial reconstruction. It simultaneously introduces new trends in the development of bioresorbable materials that could used in this field. Various studies have shown the superiority of u-HA/PLLA, a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity, compared to other bioresorbable materials. Future developments may focus on controlling its bioactivity and biodegradation rate and enhancing its mechanical strength.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.