Evidence map›Paper›PMID 35009051›Full record

ArticlePlants (Basel, Switzerland)2021

Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with

Douglas O Ochora, Esezah K Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M Wakoli, Winnie Okore, Edwin W Mwakio, Redempthah A Yeda, Agnes C Cheruiyot, Dennis W Juma and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Assessment of Anticancer Properties ofPlants (Basel, Switzerland) · 2024
    Article
  3. Synergistic Interaction of Chloroquine withIranian journal of pharmaceutical research : IJPR
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Douglas O OchoraDepartment of Plant Sciences, Microbiology & Biotechnology, College of Natural Sciences, Makerere University, Kampala P.O. Box 7062-10207, Uganda.ORCID 0000-0001-7406-7492
Esezah K KakudidiDepartment of Plant Sciences, Microbiology & Biotechnology, College of Natural Sciences, Makerere University, Kampala P.O. Box 7062-10207, Uganda.ORCID 0000-0003-3808-4126
Jane NamukobeDepartment of Chemistry, College of Natural Sciences, Makerere University, Kampala P.O. Box 7062-10207, Uganda.
Perpetua IpuletDepartment of Plant Sciences, Microbiology & Biotechnology, College of Natural Sciences, Makerere University, Kampala P.O. Box 7062-10207, Uganda.
Dancan M WakoliDepartment of Biochemistry and Molecular Biology, Egerton University, Njoro P.O. Box 536-20115, Kenya.
Winnie OkoreUnited States Army Medical Research Directorate-Kenya (USAMRD-K), Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kisumu, Kisumu P.O. Box 54-40100, Kenya.
Edwin W MwakioDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Redempthah A YedaDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Agnes C CheruiyotDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Dennis W JumaDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Ben AndagaluDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Amanda L RothDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Bernhards R OgutuCentre for Clinical Research, Kenya Medical Research Institute (KEMRI), Kisumu P.O. Box 1578-40100, Kenya.
Abiy YenesewDepartment of Chemistry, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya.ORCID 0000-0002-1123-3200
Hoseah M AkalaDepartment of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno P.O. Box Private Bag-40105, Kenya.
Maseno University · KEMakerere University · UGEgerton University · KEKenya Medical Research Institute · KEUniversity of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden. Since the deployment of artemisinin-based combination therapies (ACTs) it is clear that for a sustained fight against malaria, drug combination is one of the strategies toward malaria elimination. In Sub-Saharan Africa where malaria prevalence is the highest, the identification of plants with a novel mechanism of action that is devoid of cross-resistance is a feasible strategy in drug combination therapy. Thus, artemether and lumefantrine were separately combined and tested with extracts of

Indexed as

combinationmalariaplasmodium falciparumSecuridaca longipedunculatasynergism

Identifiers

PMID35009051
PMCPMC8747340
OpenAlexW4200505116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.