Evidence map›Paper›PMID 35008981›Full record

ArticleInternational journal of molecular sciences2022

IL-17 Pathway Members as Potential Biomarkers of Effective Systemic Treatment and Cardiovascular Disease in Patients with Moderate-to-Severe Psoriasis.

Xing Wang, Hannah Kaiser, Amanda Kvist-Hansen, Benjamin D McCauley, Lone Skov, Peter Riis Hansen, Christine Becker

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  12. Article
  13. Inflammation and Psoriasis: A Comprehensive Review.International journal of molecular sciences · 2023
    Review
  14. Multi-Omics Research Strategies for Psoriasis and Atopic Dermatitis.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xing WangDepartment of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hannah KaiserDepartment of Cardiology, University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.
Amanda Kvist-HansenDepartment of Cardiology, University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.ORCID 0000-0002-0390-9151
Benjamin D McCauleyDepartment of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lone SkovDepartment of Dermatology and Allergy, University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.ORCID 0000-0002-4784-9680
Peter Riis HansenDepartment of Cardiology, University Hospital-Herlev and Gentofte, 2900 Hellerup, Denmark.ORCID 0000-0002-9056-535X
Christine BeckerDepartment of Medicine, Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of Copenhagen · DKGentofte Hospital · DK

Funding

LEO Foundation LF16115
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory condition associated with atherosclerotic cardiovascular disease (CVD). Systemic anti-psoriatic treatments mainly include methotrexate and biological therapies targeting TNF, IL-12/23 and IL-17A. We profiled plasma proteins from patients with moderate-to-severe psoriasis to explore potential biomarkers of effective systemic treatment and their relationship to CVD. We found that systemically well-treated patients (PASI < 3.0,

Indexed as

BiomarkersSignal TransductionAgedCardiovascular DiseasesComorbidityDisease ManagementDisease SusceptibilityFemaleGene Expression ProfilingHumansImmunosuppressive AgentsInterleukin-17MaleMiddle AgedMolecular Targeted TherapyProteomeBiomarkersIL17A protein, humanImmunosuppressive AgentsInterleukin-17Proteomecardiovascular diseaseIL-17AIL-17COlinkPI3/elafinproteomicspsoriasispsoriasis area and severity index

Identifiers

PMID35008981
PMCPMC8745093
OpenAlexW4206809417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.