Evidence map›Paper›PMID 35008969›Full record

ArticleInternational journal of molecular sciences2022

Hydroxy Pentacyclic Triterpene Acid, Kaempferol, Inhibits the Human 5-Hydroxytryptamine Type 3A Receptor Activity.

Shinhui Lee, Hee-Soo Seol, Sanung Eom, Jaeeun Lee, Chaelin Kim, Jong-Hwan Park, Tae-Hwan Kim, Junho H Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Therapeutic Effects ofInternational journal of molecular sciences · 2025
    Article
  2. Phytoconstituents Targeting the Serotonin 5-HTACS pharmacology & translational science · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shinhui LeeDepartment of Biotechnology, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0002-5537-8241
Hee-Soo SeolCollege of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 61886, Korea.
Sanung EomDepartment of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Jaeeun LeeDepartment of Biotechnology, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0003-2461-2290
Chaelin KimDepartment of Biotechnology, Chonnam National University, Gwangju 61186, Korea.
Jong-Hwan ParkCollege of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 61886, Korea.
Tae-Hwan KimDepartment of Animal Science, Chonnam National University, Gwangju 61886, Korea.ORCID 0000-0002-9202-1655
Junho H LeeDepartment of Biotechnology, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0003-0913-8578
Chonnam National University · KR

Funding

National Research Foundation (NRF) funded by Korea government 2019R1F1A1059156National Research Foundation (NRF) funded by Korea government 2021R1A4A1031220
6 · The paper itself

Abstract

Monoamine serotonin is a major neurotransmitter that acts on a wide range of central nervous system and peripheral nervous system functions and is known to have a role in various processes. Recently, it has been found that 5-HT is involved in cognitive and memory functions through interaction with cholinergic pathways. The natural flavonoid kaempferol (KAE) extracted from

Indexed as

Binding SitesDose-Response Relationship, DrugHumansKaempferolsKineticsMolecular Docking SimulationMolecular Dynamics SimulationMutationPentacyclic TriterpenesProtein BindingReceptors, Serotonin, 5-HT3Serotonin 5-HT3 Receptor AntagonistsStructure-Activity RelationshipKaempferolsPentacyclic TriterpenesReceptors, Serotonin, 5-HT3Serotonin 5-HT3 Receptor Antagonistshydroxy pentacyclicKaempferolneuroprotectiveserotonin receptorTEVC

Identifiers

PMID35008969
PMCPMC8745345
OpenAlexW4206576775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.