Evidence map›Paper›PMID 35008951›Full record

ArticleInternational journal of molecular sciences2022

Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from

Sergey V Kravchenko, Pavel A Domnin, Sergei Y Grishin, Alexander V Panfilov, Viacheslav N Azev, Leila G Mustaeva, Elena Y Gorbunova, Margarita I Kobyakova, Alexey K Surin, Anna V Glyakina and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Novel Antibacterial Approaches and Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2025
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  13. Article
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  17. Ribosomes: The New Role of Ribosomal Proteins as Natural Antimicrobials.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Sergey V KravchenkoInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, 625003 Tyumen, Russia.
Pavel A DomninBiology Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia.
Sergei Y GrishinInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0001-7373-9808
Alexander V PanfilovInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.
Viacheslav N AzevThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0003-3275-4811
Leila G MustaevaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.
Elena Y GorbunovaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.
Margarita I KobyakovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Alexey K SurinInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.
Anna V GlyakinaInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.
Roman S FadeevInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Svetlana A ErmolaevaGamaleya Research Centre of Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0003-3396-6816
Oxana V GalzitskayaInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0002-3962-1520
Institute of Bioorganic Chemistry · RUInstitute of Protein Research · RUInstitute of Theoretical and Experimental Biophysics · RUGamalei Institute of Epidemiology and Microbiology · RULomonosov Moscow State University · RUUniversity of Tyumen · RU

Funding

Russian Science Foundation 18-14-00321
6 · The paper itself

Abstract

The need to develop new antimicrobial peptides is due to the high resistance of pathogenic bacteria to traditional antibiotics now and in the future. The creation of synthetic peptide constructs is a common and successful approach to the development of new antimicrobial peptides. In this work, we use a simple, flexible, and scalable technique to create hybrid antimicrobial peptides containing amyloidogenic regions of the ribosomal S1 protein from

Indexed as

Staphylococcus aureusAmino Acid SequenceAmyloidogenic ProteinsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial ProteinsCell-Penetrating PeptidesCell SurvivalDose-Response Relationship, DrugFibroblastsHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsModels, MolecularProtein ConformationProtein Interaction Domains and MotifsAmyloidogenic ProteinsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial ProteinsCell-Penetrating PeptidesRibosomal Proteinsribosomal protein S1AlphaFold 2amyloidantimicrobial peptidescell-penetrating peptideFoldAmyloidMRSAribosomal S1 proteinStaphylococcus aureus

Identifiers

PMID35008951
PMCPMC8745237
OpenAlexW4205314909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.