Evidence map›Paper›PMID 35008943›Full record

ReviewInternational journal of molecular sciences2022

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers.

Chaoran Chen, Yueming Ding, Huiyang Liu, Mengyao Sun, Honggang Wang, Dongdong Wu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chaoran ChenInstitute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China.
Yueming DingInstitute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China.
Huiyang LiuHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Mengyao SunSchool of Clinical Medicine, Henan University, Kaifeng 475004, China.
Honggang WangHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.ORCID 0000-0002-5617-3563
Dongdong WuHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.ORCID 0000-0001-6739-8437
Henan University · CN

Funding

the Graduate Education Reform and Quality Improvement Project of Henan Province (Grant No. YJS2021AL074)the grants from Construction of first-class medical disciplines in Medical College of Henan University from 2020 to 2021 for Hongggang Wang NO grant numberthe grants from key scientific and technological projects in Henan Province, China (Grant No. 202102310153) (Grant No. 202102310153)the Henan Provincial Social Science Planning Decision Consulting Project (Grant No. 2018JC38) (Grant No. 2018JC38)the innovation and Entrepreneurship Training Program for Henan University Students in 2021 (Grant number: 20211021002 and 20217003002)
6 · The paper itself

Abstract

Flubendazole, belonging to benzimidazole, is a broad-spectrum insect repellent and has been repurposed as a promising anticancer drug. In recent years, many studies have shown that flubendazole plays an anti-tumor role in different types of cancers, including breast cancer, melanoma, prostate cancer, colorectal cancer, and lung cancer. Although the anti-tumor mechanism of flubendazole has been studied, it has not been fully understood. In this review, we summarized the recent studies regarding the anti-tumor effects of flubendazole in different types of cancers and analyzed the related mechanisms, in order to provide the theoretical reference for further studies in the future.

Indexed as

AnimalsAntineoplastic AgentsBiomarkers, TumorCell Line, TumorCell ProliferationCell SurvivalClinical Studies as TopicDrug Evaluation, PreclinicalDrug MonitoringDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansMebendazoleNeoplasmsOrgan SpecificitySignal TransductionAntineoplastic AgentsBiomarkers, TumorflubendazoleMebendazoleanti-tumor rolebreast cancerflubendazolemelanomaprostate cancer

Identifiers

PMID35008943
PMCPMC8745596
OpenAlexW4206511755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.