Evidence map›Paper›PMID 35008922›Full record

ArticleInternational journal of molecular sciences2022

RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.

Kenzui Taniue, Tanzina Tanu, Yuki Shimoura, Shuhei Mitsutomi, Han Han, Rika Kakisaka, Yusuke Ono, Nobue Tamamura, Kenji Takahashi, Youichiro Wada and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kenzui TaniueIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.ORCID 0000-0003-3660-3009
Tanzina TanuIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Yuki ShimouraIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Shuhei MitsutomiIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Han HanIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Rika KakisakaInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo 065-0033, Japan.
Yusuke OnoInstitute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo 065-0033, Japan.
Nobue TamamuraCancer Genomics and Precision Medicine, Department of Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Kenji TakahashiCancer Genomics and Precision Medicine, Department of Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.
Youichiro WadaIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Yusuke MizukamiCancer Genomics and Precision Medicine, Department of Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.ORCID 0000-0002-1068-7024
Nobuyoshi AkimitsuIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
The University of Tokyo · JPAsahikawa Medical University · JPSapporo Higashi Tokushukai Hospital · JP

Funding

Japan Society for the Promotion of Science 17KK0163, 18H02570, 18KT0016, 20H03655, 20H04838, 21H04792, 21H00243, 21H02758, 21K19402
6 · The paper itself

Abstract

The RNA exosome is a multi-subunit ribonuclease complex that is evolutionally conserved and the major cellular machinery for the surveillance, processing, degradation, and turnover of diverse RNAs essential for cell viability. Here we performed integrated genomic and clinicopathological analyses of 27 RNA exosome components across 32 tumor types using The Cancer Genome Atlas PanCancer Atlas Studies' datasets. We discovered that the

Indexed as

Gene AmplificationApoptosis Regulatory ProteinsCell Line, TumorCell SurvivalExosome Multienzyme Ribonuclease ComplexExosomesGene Expression Regulation, NeoplasticHumansMitochondrial ProteinsNeoplasmsNuclear ProteinsPancreatic NeoplasmsPrognosisRNA-Binding ProteinsRNA, MessengerRNA-SeqApoptosis Regulatory ProteinsBIK protein, humanEXOSC4 protein, humanExosome Multienzyme Ribonuclease ComplexMitochondrial ProteinsNuclear ProteinsRNA-Binding ProteinsRNA, MessengerSESN2 protein, humanSestrinscell survivalEXOSC4gene amplificationPanCancerpancreatic cancerRNA exosomeTCGA

Identifiers

PMID35008922
PMCPMC8745236
OpenAlexW4205099813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.