Evidence map›Paper›PMID 35008919›Full record

ArticleInternational journal of molecular sciences2022

Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear.

Gina Perrella, Samantha J Montague, Helena C Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W M Heemskerk, Steve P Watson

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease.European heart journal. Cardiovascular pharmacotherapy · 2024
    Review
  5. Article
  6. Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation.TH open : companion journal to thrombosis and haemostasis · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Molecular Mechanisms of Hemostasis, Thrombosis and Thrombo-Inflammation.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Gina PerrellaInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.ORCID 0000-0002-0516-4261
Samantha J MontagueInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.ORCID 0000-0002-8934-3901
Helena C BrownInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.ORCID 0000-0001-7794-151X
Lourdes Garcia QuintanillaInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Alexandre SlaterInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
David StegnerInstitute of Experimental Biomedicine I, University Hospital, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-1059-9865
Mark ThomasInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Johan W M HeemskerkDepartment of Biochemistry, CARIM, Maastricht University, 6200 AC Maastricht, The Netherlands.ORCID 0000-0002-2848-5121
Steve P WatsonInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
University of Birmingham · GBMaastricht University · NLUniversity of Würzburg · DEUniversity of Nottingham · GB

Funding

British Heart Foundation CH/03/003/15571Wellcome Trust
6 · The paper itself

Abstract

Understanding the pathways involved in the formation and stability of the core and shell regions of a platelet-rich arterial thrombus may result in new ways to treat arterial thrombosis. The distinguishing feature between these two regions is the absence of fibrin in the shell which indicates that in vitro flow-based assays over thrombogenic surfaces, in the absence of coagulation, can be used to resemble this region. In this study, we have investigated the contribution of Syk tyrosine kinase in the stability of platelet aggregates (or thrombi) formed on collagen or atherosclerotic plaque homogenate at arterial shear (1000 s

Indexed as

Shear StrengthCollagenHumansPhosphorylationPlatelet AdhesivenessPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane GlycoproteinsSingle-Domain AntibodiesSyk KinaseTemperatureThrombinThrombosisCollagenPlatelet Glycoprotein GPIIb-IIIa ComplexPlatelet Membrane Glycoproteinsplatelet membrane glycoprotein VISingle-Domain AntibodiesSyk KinaseThrombindisaggregationplateletSykthrombustyrosine kinase

Identifiers

PMID35008919
PMCPMC8745592
OpenAlexW4206186740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.