Evidence map›Paper›PMID 35008861›Full record

ArticleInternational journal of molecular sciences2021

Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease.

Judith M A Verhagen, Joyce Burger, Jos A Bekkers, Alexander T den Dekker, Jan H von der Thüsen, Marina Zajec, Hennie T Brüggenwirth, Marianne L T van der Sterre, Myrthe van den Born, Theo M Luider and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Bioengineered vascular grafts with a pathogenicScience translational medicine · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The extracellular matrix glycoprotein fibrillin-1 in health and disease.Frontiers in cell and developmental biology · 2023
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Judith M A VerhagenDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0340-3433
Joyce BurgerDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jos A BekkersDepartment of Cardiothoracic Surgery, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Alexander T den DekkerCenter for Biomics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jan H von der ThüsenDepartment of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9699-4860
Marina ZajecDepartment of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Hennie T BrüggenwirthDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Marianne L T van der SterreDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Myrthe van den BornDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Theo M LuiderDepartment of Neurology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Wilfred F J van IJckenCenter for Biomics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0421-8301
Marja W WesselsDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jeroen EssersDepartment of Molecular Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Jolien W Roos-HesselinkDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-6770-3830
Ingrid van der PluijmDepartment of Molecular Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Ingrid M B H van de LaarDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-2523-1230
Erwin BrosensDepartment of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-8235-4010
Erasmus MC · NL

Funding

Erasmus University Rotterdam Fellowship to Ingrid M.B.H. van de LaarHartstichting 2014T007
6 · The paper itself

Abstract

Thoracic aortic aneurysm is a potentially life-threatening disease with a strong genetic contribution. Despite identification of multiple genes involved in aneurysm formation, little is known about the specific underlying mechanisms that drive the pathological changes in the aortic wall. The aim of our study was to unravel the molecular mechanisms underlying aneurysm formation in Marfan syndrome (MFS). We collected aortic wall samples from

Indexed as

GenomicsAdultAnimalsAortaAortic DiseasesCell RespirationFemaleFibrillin-1Gene Expression ProfilingGene Expression RegulationHumansMaleMarfan SyndromeMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionFibrillin-1Transforming Growth Factor betaMarfan syndromemitochondriaproteomicsRNA-seqthoracic aortic aneurysms

Identifiers

PMID35008861
PMCPMC8745050
OpenAlexW4205590255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.