Evidence map›Paper›PMID 35008815›Full record

ArticleInternational journal of molecular sciences2021

Dynamic Distribution of HIG2A between the Mitochondria and the Nucleus in Response to Hypoxia and Oxidative Stress.

Celia Salazar, Miriam Barros, Alvaro A Elorza, Lina María Ruiz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Antioxidants (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Celia SalazarInstitute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile.
Miriam BarrosConfocal Microscopy Laboratory, Universidad Andres Bello, Santiago 8370146, Chile.ORCID 0000-0002-0996-686X
Alvaro A ElorzaInstitute of Biomedical Sciences, Faculty of Medicine, Universidad Andres Bello, Santiago 8370146, Chile.
Lina María RuizInstitute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile.ORCID 0000-0002-9363-2730
Universidad Andrés Bello · CLUniversidad Autónoma de Chile · CL

Funding

FONDECYT 11130192FONDECYT 1180983Millennium Institute of Immunology and Immunotherapy P09-016-F
6 · The paper itself

Abstract

Mitochondrial respiratory supercomplex formation requires HIG2A protein, which also has been associated with cell proliferation and cell survival under hypoxia. HIG2A protein localizes in mitochondria and nucleus. DNA methylation and mRNA expression of the

Indexed as

Oxidative StressAnimalsCell HypoxiaCell NucleusHEK293 CellsHumansMembrane ProteinsMiceMitochondriaMitochondrial ProteinsModels, BiologicalProtein TransportSubcellular FractionsHIGD2A protein, humanHigd2a protein, mouseMembrane ProteinsMitochondrial ProteinscancerHIGD2Ahypoxiametabolic reprogramingmitochondriaoxidative stress

Identifiers

PMID35008815
PMCPMC8745331
OpenAlexW4205644549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.