Evidence map›Paper›PMID 35008814›Full record

ArticleInternational journal of molecular sciences2021

Platelet Mitochondrial Bioenergetics Reprogramming in Patients with Urothelial Carcinoma.

Patrik Palacka, Anna Gvozdjáková, Zuzana Rausová, Jarmila Kucharská, Ján Slopovský, Jana Obertová, Daniel Furka, Samuel Furka, Keshav K Singh, Zuzana Sumbalová

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Translational pediatrics · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023
    Article
  9. Article
  10. Remodeling of Mitochondria in Cancer and Other Diseases.International journal of molecular sciences · 2023
    Article
  11. Review
  12. Elevated LDL-C, high blood pressure, and low peakFrontiers in molecular biosciences · 2023
    Article
  13. Changes in CoQInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Patrik Palacka2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, Klenova 1, 833 10 Bratislava, Slovakia.ORCID 0000-0003-4505-0952
Anna GvozdjákováPharmacobiochemical Laboratory of the 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.ORCID 0000-0002-5139-9213
Zuzana RausováPharmacobiochemical Laboratory of the 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.
Jarmila KucharskáPharmacobiochemical Laboratory of the 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.
Ján Slopovský2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, Klenova 1, 833 10 Bratislava, Slovakia.
Jana Obertová2nd Department of Oncology, Faculty of Medicine, Comenius University in Bratislava, Klenova 1, 833 10 Bratislava, Slovakia.
Daniel FurkaDepartment of Physical and Theoretical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 841 04 Bratislava, Slovakia.
Samuel FurkaDepartment of Physical and Theoretical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 841 04 Bratislava, Slovakia.ORCID 0000-0002-7921-5527
Keshav K SinghDepartment of Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-0047-8616
Zuzana SumbalováPharmacobiochemical Laboratory of the 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.ORCID 0000-0001-9454-6255
Comenius University Bratislava · SKNational Institute of Cardiovascular Diseases · SKUniversity of Alabama at Birmingham · US

Funding

Mitochondria in Prostate Cancer DiversityR01CA204430 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SINGH, KESHAV K · 2016 to 2020
$1.7M
NCI NIH HHS R01 CA204430
6 · The paper itself

Abstract

Mitochondrial bioenergetics reprogramming is an essential response of cells to stress. Platelets, an accessible source of mitochondria, have a crucial role in cancer development; however, the platelet mitochondrial function has not been studied in urothelial carcinoma (UC) patients. A total of 15 patients with UC and 15 healthy controls were included in the study. Parameters of platelet mitochondrial respiration were evaluated using the high-resolution respirometry method, and the selected antioxidant levels were determined by HPLC. In addition, oxidative stress was evaluated by the thiobarbituric acid reactive substances (TBARS) concentration in plasma. We demonstrated deficient platelet mitochondrial respiratory chain functions, oxidative phosphorylation (OXPHOS), and electron transfer (ET) capacity with complex I (CI)-linked substrates, and reduced the endogenous platelet coenzyme Q

Indexed as

Energy MetabolismAdultAgedAged, 80 and overAntioxidantsBlood Cell CountBlood PlateletsCase-Control StudiesCell RespirationCitrate (si)-SynthaseFatty AcidsFemaleHumansMaleMiddle AgedMitochondriaAntioxidantsCitrate (si)-SynthaseFatty AcidsThiobarbituric Acid Reactive Substancesmitochondrial bioenergeticsoxidative stressplateletsreprogrammingurothelial carcinoma

Identifiers

PMID35008814
PMCPMC8745267
OpenAlexW4206474668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.