Evidence map›Paper›PMID 35008797›Full record

ArticleInternational journal of molecular sciences2021

DUSP-1 Induced by PGE

Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Takamitsu Konishi, Asato Maekawa, Kazuma Murata, Kengo Yamamoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Network Pharmacology andCurrent computer-aided drug design · 2025
    Article
  6. Article
  7. Review
  8. Stem ofNutrients · 2023
    Article
  9. Review
  10. Concepts of Regeneration for Spinal Diseases in 2022.International journal of molecular sciences · 2022
    Article
  11. Osteoarthritis Pain.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takuya KusakabeDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Yasunobu SawajiDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.ORCID 0000-0002-2692-0126
Kenji EndoDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Hidekazu SuzukiDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.ORCID 0000-0002-1556-1199
Takamitsu KonishiDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Asato MaekawaDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Kazuma MurataDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Kengo YamamotoDepartment of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Tokyo Medical University · JP

Funding

Japan Society for the Promotion of Science 17K11028Japan Society for the Promotion of Science 19K09609
6 · The paper itself

Abstract

The molecular mechanism of discogenic low back pain (LBP) involves nonphysiological nerve invasion into a degenerated intervertebral disc (IVD), induced by nerve growth factor (NGF). Selective cyclooxygenase (COX)-2 inhibitors are mainly used in the treatment of LBP, and act by suppressing the inflammatory mediator prostaglandin E

Indexed as

MAP Kinase Signaling SystemAdultAgedAged, 80 and overAlprostadilDinoprostoneDual Specificity Phosphatase 1HumansInterleukin-1betaIntervertebral DiscMiddle AgedNerve Growth FactorPhosphorylationProtein Kinase InhibitorsRNA, Small InterferingAlprostadilDinoprostoneDual Specificity Phosphatase 1Interleukin-1betaNerve Growth FactorProtein Kinase InhibitorsRNA, Small Interferingdual-specificity phosphatase (DUSP)-1interleukin-1β (IL-1β)intervertebral disc (IVD)mitogen-activated protein kinase (MAPK)nerve growth factor (NGF)prostaglandin E1 (PGE1)prostaglandin E2 (PGE2)

Identifiers

PMID35008797
PMCPMC8745672
OpenAlexW4200579809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.