Evidence map›Paper›PMID 35008749›Full record

ArticleInternational journal of molecular sciences2021

Intermittent Hypoxic Therapy Inhibits Allogenic Bone-Graft Resorption by Inhibition of Osteoclastogenesis in a Mouse Model.

Natasja Leth Bergholt, Ari Demirel, Michael Pedersen, Ming Ding, Tue Wenzel Kragstrup, Thomas Andersen, Bent Winding Deleuran, Casper Bindzus Foldager

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Natasja Leth BergholtOrthopaedic Research Laboratory, Aarhus University Hospital, 8200 Aarhus, Denmark.
Ari DemirelOrthopaedic Research Laboratory, Aarhus University Hospital, 8200 Aarhus, Denmark.
Michael PedersenComparative Medicine Laboratory, Aarhus University, 8200 Aarhus, Denmark.
Ming DingDepartment of Orthopaedic Surgery and Traumatology, Odense University Hospital and University of Southern Denmark, 5000 Odense, Denmark.ORCID 0000-0002-6610-8079
Tue Wenzel KragstrupDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Thomas AndersenDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Bent Winding DeleuranDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-7079-1587
Casper Bindzus FoldagerOrthopaedic Research Laboratory, Aarhus University Hospital, 8200 Aarhus, Denmark.
Aarhus University · DKAarhus University Hospital · DKUniversity of Southern Denmark · DK

Funding

Aarhus University Research Foundation AUFF-E-2015-FLS-9-7
6 · The paper itself

Abstract

Systemic Intermittent Hypoxic Therapy (IHT) relies on the adaptive response to hypoxic stress. We investigated allogenic bone-graft resorption in the lumbar spine in 48 mice. The mice were exposed to IHT for 1 week before surgery or 1 week after surgery and compared with controls after 1 and 4 weeks. Complete graft resorption was observed in 33-36% of the animals in the control group, but none in the preoperative IHT group. Increased bone-graft volume was demonstrated by micro-computed tomography in the preoperative IHT group after 1 week (

Indexed as

Bone TransplantationOsteogenesisAnimalsBone ResorptionCalcification, PhysiologicDisease Models, AnimalHypoxiaImmunityMaleMiceMice, Inbred C57BLNeovascularization, PhysiologicOsteoclastsTransplantation, Homologousboneintermittent hypoxic therapyspine

Identifiers

PMID35008749
PMCPMC8745522
OpenAlexW4200339201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.