Evidence map›Paper›PMID 35008734›Full record

ArticleInternational journal of molecular sciences2021

E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.

Noor Mustafa, Jone Mitxelena, Arantza Infante, Olatz Zenarruzabeitia, Ainhoa Eriz, Ainhoa Iglesias-Ara, Ana M Zubiaga

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Engineered CD40-biosensor-expressing Treg cells as a cell therapy approach for inflammatory diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Noor MustafaDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.ORCID 0000-0002-5264-302X
Jone MitxelenaDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.ORCID 0000-0001-8308-9546
Arantza InfanteStem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.ORCID 0000-0002-1625-2865
Olatz ZenarruzabeitiaImmunopathology Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.ORCID 0000-0002-0869-9034
Ainhoa ErizDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.ORCID 0000-0002-0196-8983
Ainhoa Iglesias-AraDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.ORCID 0000-0002-2056-8213
Ana M ZubiagaDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.ORCID 0000-0002-2132-9708
University of the Basque Country · ESBioCruces Health research Institute · ESIkerbasque · ES

Funding

Basque Government, Department of Education IT1257-19Ikerbasque Research Foundation Fellowship nsMCIU/AEI/FEDER, UE RTI2018-097497-B-100 and RED2018-102723-TUniversity of the Basque Country (UPV/EHU) Postdoctoral Fellowship ns
6 · The paper itself

Abstract

Targeted disruption of E2f2 in mice causes T-cell hyperactivation and a disproportionate cell cycle entry upon stimulation. However,

Indexed as

ApoptosisAnimalsConcanavalin AE2F2 Transcription FactorFas Ligand Proteinfas ReceptorHCT116 CellsHumansLymphocyte ActivationMiceModels, BiologicalReceptors, Antigen, T-CellSignal TransductionT-LymphocytesTranscription, GeneticTumor Suppressor Protein p53Concanavalin AE2F2 Transcription FactorFas Ligand Proteinfas ReceptorReceptors, Antigen, T-CellTumor Suppressor Protein p53apoptosisE2fFasFasLimmune disorderT lymphocytes

Identifiers

PMID35008734
PMCPMC8745065
OpenAlexW4200500002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.