Evidence map›Paper›PMID 35008682›Full record

ReviewInternational journal of molecular sciences2021

Emerging Roles of Calcium Signaling in the Development of Non-Alcoholic Fatty Liver Disease.

Chien-Chih Chen, Li-Wen Hsu, Kuang-Den Chen, King-Wah Chiu, Chao-Long Chen, Kuang-Tzu Huang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  12. Impact of static magnetic field exposure onJournal of advanced veterinary and animal research · 2025
    Article
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  15. Article
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  19. NAFLD/MAFLD: New Evidence.International journal of molecular sciences · 2023
    Article
  20. Aflatoxin BToxins · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chien-Chih ChenDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Li-Wen HsuLiver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Kuang-Den ChenLiver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
King-Wah ChiuLiver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.ORCID 0000-0003-2108-6539
Chao-Long ChenLiver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Kuang-Tzu HuangLiver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.ORCID 0000-0002-5902-3130
Kaohsiung Chang Gung Memorial Hospital · TW

Funding

Chang Gung Medical Foundation CMRPG8I0251, CMRPG8I0252
6 · The paper itself

Abstract

The liver plays a central role in energy metabolism. Dysregulated hepatic lipid metabolism is a major cause of non-alcoholic fatty liver disease (NAFLD), a chronic liver disorder closely linked to obesity and insulin resistance. NAFLD is rapidly emerging as a global health problem with currently no approved therapy. While early stages of NAFLD are often considered benign, the disease can progress to an advanced stage that involves chronic inflammation, with increased risk for developing end-stage disease including fibrosis and liver cancer. Hence, there is an urgent need to identify potential pharmacological targets. Ca

Indexed as

Calcium SignalingAnimalsEndoplasmic ReticulumHomeostasisHumansMitochondriaMolecular Targeted TherapyNon-alcoholic Fatty Liver Diseaseautophagycalciumendoplasmic reticulumlysosomemitochondrianon-alcoholic fatty liver diseasesignal transduction

Identifiers

PMID35008682
PMCPMC8745268
OpenAlexW4200408214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.