Evidence map›Paper›PMID 35008662›Full record

ArticleInternational journal of molecular sciences2021

Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure.

Antoine H Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L Gabriel Navar, David Busija, Patrice Delafontaine

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Antoine H ChaanineDepartment of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-9603-7849
LeeAnn HigginsDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Todd MarkowskiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Jarrod HarmanDepartment of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Maureen KachmanMichigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI 48109, USA.
Charles BurantDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
L Gabriel NavarDepartment of Physiology, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-3777-7564
David BusijaDepartment of Pharmacology, Tulane University, New Orleans, LA 70112, USA.
Patrice DelafontaineDepartment of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0003-3744-3617
Tulane University · USUniversity of Michigan · USUniversity of Minnesota Medical Center · USLouisiana State University Health Sciences Center New Orleans · US

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
Insulin-Like Growth Factor-1and AtherosclerosisR01HL070241 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PATRICE DELAFONTAINE · 2003 to 2026
$10.1M
Mitochondrial structure and function in cerebral arteries during diabetes and ischemic stressR01HL148836 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI BUSIJA, DAVID W · 2020 to 2023
$2.6M
NHLBI NIH HHS R01 HL070241NHLBI NIH HHS R01 HL148836NIDDK NIH HHS P30 DK089503NIH HHS AG-063345NIH HHS HL-148836NIH HHS R01-HL070241
6 · The paper itself

Abstract

Metabolic remodeling plays an important role in the pathophysiology of heart failure (HF). We sought to characterize metabolic remodeling and implicated signaling pathways in two rat models of early systolic dysfunction (MOD), and overt systolic HF (SHF). Tandem mass tag-labeled shotgun proteomics, phospho-(p)-proteomics, and non-targeted metabolomics analyses were performed in left ventricular myocardium tissue from Sham, MOD, and SHF using liquid chromatography-mass spectrometry,

Indexed as

Metabolic Networks and PathwaysMetabolomicsAdenylate KinaseAnimalsChromatography, LiquidCitric Acid CycleCyclic AMP-Dependent Protein KinasesGlycolysisHeart Failure, SystolicMass SpectrometryMitochondriaOxidative PhosphorylationRatsSignal TransductionAdenylate KinaseCyclic AMP-Dependent Protein KinasesAMPKcalcium cyclingheart failuremetabolic remodelingmitochondriaPKA

Identifiers

PMID35008662
PMCPMC8745344
OpenAlexW4200005725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.