Evidence map›Paper›PMID 35008645›Full record

ArticleInternational journal of molecular sciences2021

A Multi-Omics Network of a Seven-Gene Prognostic Signature for Non-Small Cell Lung Cancer.

Qing Ye, Brianne Falatovich, Salvi Singh, Alexey V Ivanov, Timothy D Eubank, Nancy Lan Guo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Multiomics of Aging and Aging-Related Diseases.International journal of molecular sciences · 2024
    Review
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qing YeWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Brianne FalatovichWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Salvi SinghWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Alexey V IvanovWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Timothy D EubankWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.ORCID 0000-0002-8225-7824
Nancy Lan GuoWest Virginia University Cancer Institute, Morgantown, WV 26506, USA.ORCID 0000-0002-8050-6268
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2001 to 2010
$22.8M
A Novel Computational Framework for Individualized Clinical Decision-MakingR01LM009500 · NLM · WEST VIRGINIA UNIVERSITY · PI GUO, NANCY LAN · 2008 to 2010
$987k
NCRR NIH HHS P20 RR016440NIGMS NIH HHS U54 GM104942NIH HHS R01/R56LM009500, P20RR16440 and ARRA Supplement, and NIGMS/XLerateHealth LLC (4UT2GM130174) I2P AwardNLM NIH HHS R01 LM009500
6 · The paper itself

Abstract

There is an unmet clinical need to identify patients with early-stage non-small cell lung cancer (NSCLC) who are likely to develop recurrence and to predict their therapeutic responses. Our previous study developed a qRT-PCR-based seven-gene microfluidic assay to predict the recurrence risk and the clinical benefits of chemotherapy. This study showed it was feasible to apply this seven-gene panel in RNA sequencing profiles of The Cancer Genome Atlas (TCGA) NSCLC patients (

Indexed as

AnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationClustered Regularly Interspaced Short Palindromic RepeatsDNA Copy Number VariationsGene Expression Regulation, NeoplasticHumansKruppel-Like Transcription FactorsLung NeoplasmsMicePrognosisRNA InterferenceSignal TransductionTranscription, GeneticKruppel-Like Transcription FactorsBoolean implication networkschemotherapyCRISPR-Cas9drug repositionimmune checkpoint inhibitormulti-omicsnon-small cell lung cancerprognostic gene signatureradiotherapyRNA interference

Identifiers

PMID35008645
PMCPMC8745553
OpenAlexW4200114037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.