Evidence map›Paper›PMID 35008598›Full record

ArticleInternational journal of molecular sciences2021

Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells.

Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michał Chodyński, Ewa Marcinkowska, Enikö Kallay, Martin Schepelmann

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  10. Structure and the Anticancer Activity of Vitamin D Receptor Agonists.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Karina PiatekInstitute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Andrzej KutnerDepartment of Bioanalysis and Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.ORCID 0000-0002-9518-4142
Dan Cacsire Castillo-TongTranslational Gynecology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
Teresa ManhardtInstitute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Nadja KupperInstitute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0001-6497-024X
Urszula NowakFaculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.ORCID 0000-0001-8958-4142
Michał ChodyńskiŁukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera, 01-793 Warsaw, Poland.ORCID 0000-0002-6950-6515
Ewa MarcinkowskaFaculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.ORCID 0000-0002-6808-5464
Enikö KallayInstitute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-4996-0104
Martin SchepelmannInstitute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-7017-5426
Medical University of Vienna · ATUniversity of Wrocław · PLComprehensive Cancer Center Vienna · ATŁukasiewicz Research Network - Industrial Chemistry Institute · PLMedical University of Warsaw · PL

Funding

Austrian Science Fund FWF P 29948FWF Austrian Science Fund P 29948-B28FWF Austrian Science Fund P 32840-BRichard and Ethel Herzfeld Foundation P 32840-BThe National Science Centre of Poland OPUS 2015/17/B/NZ4/02632
6 · The paper itself

Abstract

backgroundOvarian cancer (OC) is one of the most lethal cancers in women. The active form of vitamin D

methodsWe used two patient-derived high-grade serous ovarian cancer (HGSOC) cell lines with low (13781) and high (14433) mRNA expression levels of the gene encoding 1,25-dihydroxyvitamin D

results

conclusionsThe an1,25Ds had different potencies in the HGSOC cell lines and their efficacy in increasing

Indexed as

Cell SurvivalAntineoplastic AgentsCell Line, TumorCells, CulturedErgocalciferolsFemaleGene Expression Regulation, NeoplasticHumansOvarian NeoplasmsReceptors, CalcitriolVitamin DVitamin D3 24-Hydroxylase1,25-dihydroxyergocalciferol24a-homo-1,15-dihydroxyergocalciferolAntineoplastic AgentsErgocalciferolsReceptors, CalcitriolVDR protein, humanVitamin DVitamin D3 24-Hydroxylase25 vitamin D 24-hydroxylaseCYP24A1high-grade serous ovarian cancer cellsproliferationvitamin Dvitamin D analogs

Identifiers

PMID35008598
PMCPMC8745402
OpenAlexW4200479380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.