Evidence map›Paper›PMID 35008574›Full record

ReviewInternational journal of molecular sciences2021

Roles of Oxytocin in Stress Responses, Allostasis and Resilience.

Yuki Takayanagi, Tatsushi Onaka

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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  7. Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuki TakayanagiDivision of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Tochigi 329-0498, Japan.ORCID 0000-0003-3788-8229
Tatsushi OnakaDivision of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Tochigi 329-0498, Japan.
Jichi Medical University · JP

Funding

Japan Science and Technology Agency JPMJFR2067Japan Society for the Promotion of Science 20H03419Japan Society for the Promotion of Science 20K07278
6 · The paper itself

Abstract

Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for psychosocial behavior and reproductive functions. Oxytocin neurons are activated by various stressful stimuli. The oxytocin receptor is widely distributed within the brain, and oxytocin that is released or diffused affects behavioral and neuroendocrine stress responses. On the other hand, there has been an increasing number of reports on the role of oxytocin in allostasis and resilience. It has been shown that oxytocin maintains homeostasis, shifts the set point for adaptation to a changing environment (allostasis) and contributes to recovery from the shifted set point by inducing active coping responses to stressful stimuli (resilience). Recent studies have suggested that oxytocin is also involved in stress-related disorders, and it has been shown in clinical trials that oxytocin provides therapeutic benefits for patients diagnosed with stress-related disorders. This review includes the latest information on the role of oxytocin in stress responses and adaptation.

Indexed as

Adaptation, PsychologicalAllostasisAnimalsAnxietyHumansNeuronsOxytocinReceptors, OxytocinResilience, PsychologicalStress, PsychologicalOxytocinReceptors, Oxytocinallostasishypothalamusoxytocinresiliencestress

Identifiers

PMID35008574
PMCPMC8745417
OpenAlexW4200338147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.