Evidence map›Paper›PMID 35008548›Full record

ArticleInternational journal of molecular sciences2021

Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples.

Viktória Németh, Szabina Horváth, Ágnes Kinyó, Rolland Gyulai, Zsuzsanna Lengyel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
  3. Review
  4. Traumatic brain injury-related ferroptosis: current perspectives.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  5. Article
  6. The Impact of Sleep Quality on Skin Color.Indian dermatology online journal · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Viktória NémethDepartment of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, H-7632 Pecs, Hungary.ORCID 0000-0001-6452-9817
Szabina HorváthDepartment of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, H-7632 Pecs, Hungary.ORCID 0000-0002-5168-1622
Ágnes KinyóDepartment of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, H-7632 Pecs, Hungary.
Rolland GyulaiDepartment of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, H-7632 Pecs, Hungary.ORCID 0000-0002-3286-8846
Zsuzsanna LengyelDepartment of Dermatology, Venereology and Oncodermatology, Medical School, University of Pécs, H-7632 Pecs, Hungary.
University of Pecs · HU

Funding

National Research, Development and Innovation Office 128832
6 · The paper itself

Abstract

Psoriasis is a systemic inflammatory skin disorder that can be associated with sleep disturbance and negatively influence the daily rhythm. The link between the pathomechanism of psoriasis and the circadian rhythm has been suggested by several previous studies. However, there are insufficient data on altered clock mechanisms in psoriasis to prove these theories. Therefore, we investigated the expression of the core clock genes in human psoriatic lesional and non-lesional skin and in human adult low calcium temperature (HaCaT) keratinocytes after stimulation with pro-inflammatory cytokines. Furthermore, we examined the clock proteins in skin biopsies from psoriatic patients by immunohistochemistry. We found that the clock gene transcripts were elevated in psoriatic lesions, especially in non-lesional psoriatic areas, except for

Indexed as

AdultCell LineCircadian RhythmCLOCK ProteinsCytokinesDown-RegulationEpidermisHaCaT CellsHumansInflammationKeratinocytesPsoriasisRNA, MessengerSkinCLOCK ProteinsCytokinesRNA, Messengercircadian rhythmpsoriasisskin

Identifiers

PMID35008548
PMCPMC8745255
OpenAlexW4200466484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.