Evidence map›Paper›PMID 35008547›Full record

ArticleInternational journal of molecular sciences2021

Bioprinted Cancer Model of Neuroblastoma in a Renal Microenvironment as an Efficiently Applicable Drug Testing Platform.

Dongwei Wu, Johanna Berg, Birte Arlt, Viola Röhrs, Munir A Al-Zeer, Hedwig E Deubzer, Jens Kurreck

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Beyond monolayers: a comparative analysis of 2D cell cultures and 3DFrontiers in bioengineering and biotechnology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Xeno-Free 3D Bioprinted Liver Model for Hepatotoxicity Assessment.International journal of molecular sciences · 2024
    Article
  8. Review
  9. Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing.International journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dongwei WuInstitute of Biotechnology, Chair of Applied Biochemistry, Technische Universität Berlin, 13355 Berlin, Germany.ORCID 0000-0001-5446-7376
Johanna BergInstitute of Biotechnology, Chair of Applied Biochemistry, Technische Universität Berlin, 13355 Berlin, Germany.
Birte ArltDepartment of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-6665-4037
Viola RöhrsInstitute of Biotechnology, Chair of Applied Biochemistry, Technische Universität Berlin, 13355 Berlin, Germany.
Munir A Al-ZeerInstitute of Biotechnology, Chair of Applied Biochemistry, Technische Universität Berlin, 13355 Berlin, Germany.
Hedwig E DeubzerDepartment of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-6115-4893
Jens KurreckInstitute of Biotechnology, Chair of Applied Biochemistry, Technische Universität Berlin, 13355 Berlin, Germany.ORCID 0000-0002-1469-0052
Technische Universität Berlin · DECharité - Universitätsmedizin Berlin · DEMax Delbrück Center · DE

Funding

Chinese Scholarship Council 201906780024City of Berlin Prize for the Development of Alternatives to Animal ExperimentationEinstein Foundation EZ-2020-597-2Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen none
6 · The paper itself

Abstract

Development of new anticancer drugs with currently available animal models is hampered by the fact that human cancer cells are embedded in an animal-derived environment. Neuroblastoma is the most common extracranial solid malignancy of childhood. Major obstacles include managing chemotherapy-resistant relapses and resistance to induction therapy, leading to early death in very-high-risk patients. Here, we present a three-dimensional (3D) model for neuroblastoma composed of IMR-32 cells with amplified genes of the

Indexed as

Anaplastic Lymphoma KinaseAntineoplastic AgentsApoptosisCell DeathCell LineCell Line, TumorCell ProliferationFibroblastsHEK293 CellsHumansKidneyNeuroblastomaN-Myc Proto-Oncogene ProteinPanobinostatTumor MicroenvironmentAnaplastic Lymphoma KinaseAntineoplastic AgentsN-Myc Proto-Oncogene ProteinPanobinostatbioprintingcancer modeldrug testingneuroblastomapanobinostat

Identifiers

PMID35008547
PMCPMC8745467
OpenAlexW4200105539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.