ArticleInternational journal of molecular sciences2021
From Molecules to Behavior in Long-Term Inorganic Mercury Intoxication: Unraveling Proteomic Features in Cerebellar Neurodegeneration of Rats.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Heavy metal toxicity as a driver of endoplasmic reticulum stress and dysfunction.The FEBS journal · 2026Review
- Hesperidin Attenuates Mercury Chloride-Induced Neurotoxicity in Rats by Modulating Oxidative Stress, Neuroinflammation, Apoptosis, Autophagy and ER Stress.Biological trace element research · 2026Article
- Intermittent fasting and exercise: a dual intervention for orchestrating glycolipid conversion and utilization in healthy mice.Molecular and cellular biochemistry · 2025Article
- A Brazilian Minamata disease? Neurologists must be aware of mercury exposure and intoxication.Arquivos de neuro-psiquiatria · 2025Review
- Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer.Medical oncology (Northwood, London, England) · 2025Article
- Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis.Heliyon · 2025Article
- Plasma Proteome Alterations of Laying Hens Subjected to Heat Stress and Fed a Diet Supplemented with Pequi Oil (Biomolecules · 2024Article
- Review
- Metalloproteomic Investigation of Hg-Binding Proteins in Renal Tissue of Rats Exposed to Mercury Chloride.International journal of molecular sciences · 2023Article
- Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism.Environmental geochemistry and health · 2023Article
- Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health.Frontiers in public health · 2023Article
- Neurodegenerative Diseases: From Molecular Basis to Therapy.International journal of molecular sciences · 2022Article
- Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?International journal of molecular sciences · 2022Article
- Article
- Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats.International journal of molecular sciences · 2022Article
- Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study.Toxicology reports · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mercury is a severe environmental pollutant with neurotoxic effects, especially when exposed for long periods. Although there are several evidences regarding mercury toxicity, little is known about inorganic mercury (IHg) species and cerebellum, one of the main targets of mercury associated with the neurological symptomatology of mercurial poisoning. Besides that, the global proteomic profile assessment is a valuable tool to screen possible biomarkers and elucidate molecular targets of mercury neurotoxicity; however, the literature is still scarce. Thus, this study aimed to investigate the effects of long-term exposure to IHg in adult rats' cerebellum and explore the modulation of the cerebellar proteome associated with biochemical and functional outcomes, providing evidence, in a translational perspective, of new mercury toxicity targets and possible biomarkers. Fifty-four adult rats were exposed to 0.375 mg/kg of HgCl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.