Evidence map›Paper›PMID 35008536›Full record

ArticleInternational journal of molecular sciences2021

The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses.

Camille Jacques, Mathias Chatelais, Karim Fekir, Louis Fauconnier, Manon Mellier, Dieudonnée Togbe, Ilaria Floris

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Active Substances from the Micro-Immunotherapy Medicine 2LC1International journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Actives from the Micro-Immunotherapy Medicine 2LMIREGJournal of inflammation research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Camille JacquesPreclinical Research Department, Labo'Life France, 1 Rue François Bruneau, 44000 Nantes, France.
Mathias ChatelaisProfileHIT SASU, 7 Rue du Buisson, 44680 Sainte-Pazanne, France.
Karim FekirProfileHIT SASU, 7 Rue du Buisson, 44680 Sainte-Pazanne, France.
Louis FauconnierArtImmune SAS, 13 Avenue Buffon, 45100 Orleans, France.
Manon MellierArtImmune SAS, 13 Avenue Buffon, 45100 Orleans, France.
Dieudonnée TogbeCentre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche 7355 (UMR7355), 3 B Rue de la Ferollerie, CEDEX 2, 45071 Orleans, France.ORCID 0000-0001-6658-414X
Ilaria FlorisPreclinical Research Department, Labo'Life France, 1 Rue François Bruneau, 44000 Nantes, France.ORCID 0000-0003-4089-3133
Université d'Orléans · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed at evaluating the effects of the micro-immunotherapy medicine (MIM) 2LEID, both in vitro and in vivo, on several components of the innate and adaptive immune system. MIM increased the phagocytic activity of macrophages, and it augmented the expression of the activation markers CD69 and HLA-DR in NK cells and monocytes/macrophages, respectively. The effect of MIM was evaluated in a model of respiratory infection induced by

Indexed as

Adaptive ImmunityAdjuvants, ImmunologicAnimalsBiomarkersCell ProliferationCells, CulturedCytokinesEndothelial CellsFemaleHumansImmunity, InnateImmunotherapyInterleukin-10Killer Cells, NaturalLeukocytes, MononuclearLungAdjuvants, ImmunologicBiomarkersCytokinesInterleukin-102LEID, immunostimulant drughost defensesinfluenza A virusinnate and adaptative immunitylow dosemicro-immunotherapyrespiratory infectious diseases

Identifiers

PMID35008536
PMCPMC8744989
OpenAlexW4200059482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.