Evidence map›Paper›PMID 35008503›Full record

ArticleInternational journal of molecular sciences2021

Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle

Dieter Blottner, Gabor Trautmann, Sandra Furlan, Guido Gambara, Katharina Block, Martina Gutsmann, Lian-Wen Sun, Paul F Worley, Luisa Gorza, Martina Scano and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Increased Homer Activity and NMJ Localization in the Vestibular LesionInternational journal of molecular sciences · 2024
    Article
  6. Review
  7. Cellular and Molecular Signaling Meet the Space Environment.International journal of molecular sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Dieter BlottnerCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Integrative Neuroanatomy, 10117 Berlin, Germany.ORCID 0000-0003-0355-3340
Gabor TrautmannCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Integrative Neuroanatomy, 10117 Berlin, Germany.
Sandra FurlanC.N.R. Institute of Neuroscience, 35121 Padova, Italy.
Guido GambaraNeuromuscular System and Neuromuscular Signaling, Center of Space Medicine Berlin, 10115 Berlin, Germany.
Katharina BlockNeuromuscular System and Neuromuscular Signaling, Center of Space Medicine Berlin, 10115 Berlin, Germany.ORCID 0000-0002-2752-5232
Martina GutsmannCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Integrative Neuroanatomy, 10117 Berlin, Germany.
Lian-Wen SunBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Paul F WorleyDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.
Luisa GorzaDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0003-4897-400X
Martina ScanoDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Paola LorenzonDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0002-9526-6471
Imre VidaCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Integrative Neuroanatomy, 10117 Berlin, Germany.ORCID 0000-0003-3214-2233
Pompeo VolpeDepartment of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Michele SalanovaCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Institute of Integrative Neuroanatomy, 10117 Berlin, Germany.ORCID 0000-0002-7066-3876
Humboldt-Universität zu Berlin · DEUniversity of Padua · ITBeihang University · CNJohns Hopkins University · USNeuroscience Institute · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms of skeletal muscle atrophy under extended periods of either disuse or microgravity are not yet fully understood. The transition of Homer isoforms may play a key role during neuromuscular junction (NMJ) imbalance/plasticity in space. Here, we investigated the expression pattern of Homer short and long isoforms by gene array, qPCR, biochemistry, and laser confocal microscopy in skeletal muscles from male C57Bl/N6 mice (

Indexed as

AnimalsHindlimb SuspensionHomer Scaffolding ProteinsMaleMiceMice, Inbred C57BLMuscle ProteinsMuscle, SkeletalMuscular AtrophyNeuromuscular JunctionProtein IsoformsRatsRats, Sprague-DawleyRats, WistarSpace FlightWeightlessnessHomer1 protein, mouseHomer2 protein, mouseHomer Scaffolding ProteinsMuscle ProteinsProtein Isoformshindlimb unloadingHomer isoform switchmicrogravitymuscle atrophyNMJ adaptation

Identifiers

PMID35008503
PMCPMC8744925
OpenAlexW4200171460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.