Evidence map›Paper›PMID 35008501›Full record

ArticleInternational journal of molecular sciences2021

Possible Role of Circulating Bone Marrow Mesenchymal Progenitors in Modulating Inflammation and Promoting Wound Repair.

Laura Grech, Jean-Paul Ebejer, Oriana Mazzitelli, Kevin Schembri, Joseph Borg, Elisa Seria

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laura GrechCentre for Molecular Medicine and Biobanking, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0002-1661-7158
Jean-Paul EbejerCentre for Molecular Medicine and Biobanking, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0003-0888-2637
Oriana MazzitelliCentre for Molecular Medicine and Biobanking, University of Malta, MSD 2080 Msida, Malta.
Kevin SchembriDepartment of Surgery, Faculty of Medicine and Surgery, University of Malta Medical School and Mater Dei Hospital, MSD 2080 Msida, Malta.
Joseph BorgDepartment of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0002-2220-5651
Elisa SeriaCentre for Molecular Medicine and Biobanking, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0002-3003-4151
University of Malta · MT

Funding

TAKE OFF seed fund award E20LG68-01The University of Malta Research Excellence Fund I20LU05
6 · The paper itself

Abstract

Circulating bone marrow mesenchymal progenitors (BMMPs) are known to be potent antigen-presenting cells that migrate to damaged tissue to secrete cytokines and growth factors. An altered or dysregulated inflammatory cascade leads to a poor healing outcome. A skin model developed in our previous study was used to observe the immuno-modulatory properties of circulating BMMP cells in inflammatory chronic wounds in a scenario of low skin perfusion. BMMPs were analysed exclusively and in conjunction with recombinant tumour necrosis factor alpha (TNFα) and recombinant hepatocyte growth factor (HGF) supplementation. We analysed the expression levels of interleukin-8 (

Indexed as

5'-NucleotidaseAdipocytesBiomarkersBone MarrowBone Marrow CellsCells, CulturedChondrocytesFibroblast Growth Factor 1Hepatocyte Growth FactorHumansInflammationInterleukin-8Mesenchymal Stem CellsOsteocytesRecombinant ProteinsSkin5'-NucleotidaseBiomarkersFibroblast Growth Factor 1Hepatocyte Growth FactorInterleukin-8Recombinant ProteinsTumor Necrosis Factor-alphabone marrow mesenchymal progenitor cellsinflammationwound healing

Identifiers

PMID35008501
PMCPMC8744598
OpenAlexW4200027789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.