Evidence map›Paper›PMID 35008494›Full record

ArticleInternational journal of molecular sciences2021

Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells.

Kana Marunaka, Shokoku Shu, Mao Kobayashi, Makiko Goto, Yuji Katsuta, Yuta Yoshino, Akira Ikari

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Intracellular MgCommunications biology · 2023
    Article
  10. Editorial: Special Issue, "Molecular Advances in Skin Diseases".International journal of molecular sciences · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kana MarunakaLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Shokoku ShuLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Mao KobayashiLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Makiko GotoMIRAI Technology Institute, Shiseido Co. Ltd., Kanagawa 220-0011, Japan.
Yuji KatsutaMIRAI Technology Institute, Shiseido Co. Ltd., Kanagawa 220-0011, Japan.
Yuta YoshinoLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
Akira IkariLaboratory of Biochemistry, Department of Biopharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 501-1196, Japan.ORCID 0000-0003-2696-0897
Gifu Pharmaceutical University · JPMirai Hospital · JP

Funding

This work was supported in part by collaborative research grant from Shiseido Co., Ltd. (Kanagawa, Japan) JSPS KAKENHI Grant Number 19H03373
6 · The paper itself

Abstract

Skin barrier damage is present in the patients with hereditary disorders of the magnesium channel, but the molecular mechanism has not been fully understood. We found that the expressions of hyaluronan synthase (HAS), HAS2 and HAS3 are influenced by MgCl

Indexed as

Cell LineCyclic AMP Response Element-Binding ProteinDietary SupplementsGlycogen Synthase Kinase 3HaCaT CellsHumansHyaluronan SynthasesHyaluronic AcidKeratinocytesMagnesiumRNA, MessengerSignal TransductionSkinUp-RegulationCREB1 protein, humanCyclic AMP Response Element-Binding ProteinGlycogen Synthase Kinase 3Hyaluronan SynthasesHyaluronic AcidMagnesiumRNA, Messengerhyaluronan synthasehyaluronic acidmagnesium

Identifiers

PMID35008494
PMCPMC8744730
OpenAlexW4200340709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.