Evidence map›Paper›PMID 35008491›Full record

ArticleInternational journal of molecular sciences2021

Fibrosis Protein-Protein Interactions from Google Matrix Analysis of MetaCore Network.

Ekaterina Kotelnikova, Klaus M Frahm, Dima L Shepelyansky, Oksana Kunduzova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Opinion Formation in the World Trade Network.Entropy (Basel, Switzerland) · 2024
    Article
  3. Recent Advances in Protein-Protein Interactions.International journal of molecular sciences · 2023
    Article
  4. COVID-19's Impact on International Trade.Entropy (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ekaterina KotelnikovaClarivate Analytics, 08025 Barcelona, Spain.ORCID 0000-0002-8026-078X
Klaus M FrahmLaboratoire de Physique Théorique, IRSAMC, Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.ORCID 0000-0002-4077-3337
Dima L ShepelyanskyLaboratoire de Physique Théorique, IRSAMC, Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.ORCID 0000-0002-2752-0765
Oksana KunduzovaNational Institute of Health and Medical Research (INSERM) U1048, CEDEX 4, 31432 Toulouse, France.ORCID 0000-0003-2503-6555
Centre National de la Recherche Scientifique · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

ANR France ANR-17-EURE-0009
6 · The paper itself

Abstract

Protein-protein interactions is a longstanding challenge in cardiac remodeling processes and heart failure. Here, we use the MetaCore network and the Google matrix algorithms for prediction of protein-protein interactions dictating cardiac fibrosis, a primary cause of end-stage heart failure. The developed algorithms allow identification of interactions between key proteins and predict new actors orchestrating fibroblast activation linked to fibrosis in mouse and human tissues. These data hold great promise for uncovering new therapeutic targets to limit myocardial fibrosis.

Indexed as

AlgorithmsAnimalsFibrosisHeart FailureHumansMiceMyocardiumProtein Interaction MapsSearch EngineVentricular Remodelingdirected networksfibrosisGoogle matrixMarkov chainsprotein–protein interactions

Identifiers

PMID35008491
PMCPMC8744902
OpenAlexW4225493853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.