Evidence map›Paper›PMID 35008319›Full record

ArticleCancers2021

Immune-Mediated Effects of Microplanar Radiotherapy with a Small Animal Irradiator.

Soha Bazyar, Edward Timothy O'Brien, Thad Benefield, Victoria R Roberts, Rashmi J Kumar, Gaorav P Gupta, Otto Zhou, Yueh Z Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soha BazyarDepartment of Radiation Oncology, University of Maryland, Maryland, MD 21201, USA.ORCID 0000-0002-8425-8281
Edward Timothy O'BrienDepartment of Physics and Astronomy, The University of North Carolina, Chapel Hill, NC 27514, USA.
Thad BenefieldDepartment of Radiology, The University of North Carolina, Chapel Hill, NC 27514, USA.
Victoria R RobertsSchool of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-2665-7636
Rashmi J KumarMedical Scientist Training Program, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Gaorav P GuptaDepartment of Radiation Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Otto ZhouDepartment of Applied Physics Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Yueh Z LeeDepartment of Radiology, The University of North Carolina, Chapel Hill, NC 27514, USA.ORCID 0000-0003-1846-7680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatially fractionated radiotherapy has been shown to have effects on the immune system that differ from conventional radiotherapy (CRT). We compared several aspects of the immune response to CRT relative to a model of spatially fractionated radiotherapy (RT), termed microplanar radiotherapy (MRT). MRT delivers hundreds of grays of radiation in submillimeter beams (peak), separated by non-radiated volumes (valley). We have developed a preclinical method to apply MRT by a commercial small animal irradiator. Using a B16-F10 murine melanoma model, we first evaluated the in vitro and in vivo effect of MRT, which demonstrated significant treatment superiority relative to CRT. Interestingly, we observed insignificant treatment responses when MRT was applied to Rag

Indexed as

combined radio-immunotherapymicrobeam radiation therapymicroplanar radiation therapyspatially fractionated radiation therapy

Identifiers

PMID35008319
PMCPMC8750301

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.