Evidence map›Paper›PMID 35008218›Full record

ArticleCancers2021

Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas.

Lena Kaiser, Adrien Holzgreve, Stefanie Quach, Michael Ingrisch, Marcus Unterrainer, Franziska J Dekorsy, Simon Lindner, Viktoria Ruf, Julia Brosch-Lenz, Astrid Delker and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. The confounding effects of microvascular physiology on the uptake and diagnostic accuracy of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Article
  5. Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Feasibility of radiomic feature harmonization for pooling of [Zeitschrift fur medizinische Physik · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Longitudinal [Biomedicines · 2022
    Article
  16. Article
  17. Reduced Acquisition Time [Frontiers in medicine · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 1 country.

Lena KaiserDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-2084-5858
Adrien HolzgreveDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-9566-8438
Stefanie QuachDepartment of Neurosurgery, University Hospital, LMU Munich, 81377 Munich, Germany.
Michael IngrischDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Marcus UnterrainerDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-8238-1198
Franziska J DekorsyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Simon LindnerDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Viktoria RufCenter for Neuropathology and Prion Research, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-3876-8854
Julia Brosch-LenzDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Astrid DelkerDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Guido BöningDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.ORCID 0000-0003-0986-2929
Bogdana SuchorskaDepartment of Neurosurgery, Sana Hospital, 47055 Duisburg, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital, LMU Munich, 81377 Munich, Germany.
Christian H WetzelDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-5762-0003
Markus J RiemenschneiderDepartment of Neuropathology, University Hospital Regensburg, 93053 Regensburg, Germany.
Sophia StöckleinDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.
Niklas ThonDepartment of Neurosurgery, University Hospital, LMU Munich, 81377 Munich, Germany.
Louisa von BaumgartenDepartment of Neurosurgery, University Hospital, LMU Munich, 81377 Munich, Germany.
Jörg-Christian TonnDepartment of Neurosurgery, University Hospital, LMU Munich, 81377 Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Sibylle ZieglerDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
LMU Klinikum · DEGerman Cancer Research Center · DEUniversity of Regensburg · DELudwig-Maximilians-Universität München · DEUniversity Hospital Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft FOR 2858 project number 421887978Deutsche Forschungsgemeinschaft Research Training Group GRK 2274Else Kröner-Fresenius-Stiftung N.L.A.
6 · The paper itself

Abstract

In this study, dual PET and contrast enhanced MRI were combined to investigate their correlation per voxel in patients at initial diagnosis with suspected glioblastoma. Correlation with contrast enhancement (CE) as an indicator of BBB leakage was further used to evaluate whether PET signal is likely caused by BBB disruption alone, or rather attributable to specific binding after BBB passage. PET images with [

Indexed as

amino acid PETcontrast enhancementFET PETgliomaspatial correlationTSPO PET

Identifiers

PMID35008218
PMCPMC8750092
OpenAlexW4225823760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.