Evidence map›Paper›PMID 35008188›Full record

ArticleCancers2021

tRNA

Konstantina Panoutsopoulou, Tobias Dreyer, Julia Dorn, Eva Obermayr, Sven Mahner, Toon van Gorp, Ioana Braicu, Robert Zeillinger, Viktor Magdolen, Margaritis Avgeris and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Identification of Oncogene-Induced Senescence-Associated MicroRNAs.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. High Intratumoral i-tRF-GlyBiomedicines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Konstantina PanoutsopoulouDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0003-2773-4883
Tobias DreyerClinical Research Unit, Department of Obstetrics and Gynecology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Julia DornClinical Research Unit, Department of Obstetrics and Gynecology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Eva ObermayrMolecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6324-2961
Sven MahnerDepartment of Gynecology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Toon van GorpDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospital Leuven, Leuven Cancer Institute, 3000 Leuven, Belgium.
Ioana BraicuDepartment of Gynecology, Campus Virchow, Charité University Medicine, 13353 Berlin, Germany.
Robert ZeillingerMolecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6771-4591
Viktor MagdolenClinical Research Unit, Department of Obstetrics and Gynecology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0003-0167-793X
Margaritis AvgerisDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-2135-9886
Andreas ScorilasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0003-2427-4949
National and Kapodistrian University of Athens · GRTechnical University of Munich · DEComprehensive Cancer Center Vienna · ATCharité - Universitätsmedizin Berlin · DEKU Leuven · BEUniversität Hamburg · DE

Funding

Stavros Niarchos Foundation 16785
6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) remains a highly-lethal gynecological malignancy, characterized by frequent recurrence, chemotherapy resistance and poor 5-year survival. Identifying novel predictive molecular markers remains an overdue challenge in the disease's clinical management. Herein, in silico analysis of TCGA-OV highlighted the tRNA-derived internal fragment (i-tRF-GlyGCC) among the most abundant tRFs in ovarian tumors, while target prediction and gene ontology (GO) enrichment analysis predicted its implication in key biological processes. Thereafter, i-tRF-GlyGCC levels were quantified in a screening EOC (

Indexed as

internal tRFsitRFmolecular diagnosticsnon-coding RNAs (ncRNAs)transfer RNAstRFstRNA-derived small fragments (tsRNAs)tRNA fragments

Identifiers

PMID35008188
PMCPMC8750938
OpenAlexW4200484940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.