Evidence map›Paper›PMID 35008168›Full record

ArticleCancers2021

Prognostic Significance of

Victoria Tserpeli, Dimitra Stergiopoulou, Dora Londra, Lydia Giannopoulou, Paul Buderath, Ioanna Balgkouranidou, Nikolaos Xenidis, Christina Grech, Eva Obermayr, Robert Zeillinger and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  13. Article
  14. Ovarian Cancer Diagnosis and Prognosis Based on Cell-Free DNA Methylation.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Victoria TserpeliAnalysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Dimitra StergiopoulouAnalysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Dora LondraAnalysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Lydia GiannopoulouAnalysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Paul BuderathDepartment of Gynecology and Obstetrics, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.
Ioanna BalgkouranidouDepartment of Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Nikolaos XenidisDepartment of Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Christina GrechDepartment of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0414-8814
Eva ObermayrDepartment of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6324-2961
Robert ZeillingerDepartment of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6771-4591
Kitty PavlakisPathology Department, IASO Women's Hospital, 15123 Athens, Greece.
Theodoros RampiasBasic Research Center, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0002-5460-5334
Stylianos KakolyrisDepartment of Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Sabine Kasimir-BauerDepartment of Gynecology and Obstetrics, University Hospital of Essen, University of Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.ORCID 0000-0002-8081-1799
Evi S LianidouAnalysis of Circulating Tumor Cells, Lab of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-7796-5914
National and Kapodistrian University of Athens · GRDemocritus University of Thrace · GRMedical University of Vienna · ATUniversity of Duisburg-Essen · DEBiomedical Research Foundation of the Academy of Athens · GRIASO General Hospital · GR

Funding

the European Union and Greek National funds through the Operational Program Competitive-ness, Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE T1RCI-02935
6 · The paper itself

Abstract

backgroundEpigenetic alterations in ctDNA are highly promising as a source of novel potential liquid biopsy biomarkers and comprise a very promising liquid biopsy approach in ovarian cancer, for early diagnosis, prognosis and response to treatment.

methodsIn the present study, we examined the methylation status of six gene promoters (

resultsWe report for the first time that the DNA methylation of

conclusionsOur results strongly indicate that

Indexed as

DNA methylationhigh-grade serous ovarian cancerliquid biopsymethylation specific PCRplasma cell-free DNAprognostic biomarkerprogression free survivalSchlaffen11

Identifiers

PMID35008168
PMCPMC8750111
OpenAlexW4200269115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.