Evidence map›Paper›PMID 35008061›Full record

ArticleThe American journal of tropical medicine and hygiene2022

Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect®).

Dirk Debus, Semra Genç, Philipp Kurz, Martin Holzer, Kurt Bauer, Ralph Heimke-Brinck, Martin Baier, Heidi Sebald, Andrea Debus, Christian Bogdan and 1 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Dirk DebusDepartment of Dermatology, Paracelsus Medizinische Privatuniversität, Klinikum Nürnberg, Prof.-Ernst-Nathan-Straße 1, Germany.
Semra GençInstitute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany.
Philipp KurzInstitute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstraße 21, Freiburg, Germany.
Martin HolzerInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany.
Kurt BauerInstitute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universität, Hermann-Herder-Straße 9, Freiburg, Germany.
Ralph Heimke-BrinckPharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany.
Martin BaierPharmacy Department, Universitätsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany.
Heidi SebaldMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany.
Andrea DebusMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany.
Christian BogdanMikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, Erlangen, Germany.
Kurt-Wilhelm StahlWaisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, Günterstalstraße 60, Freiburg, Germany.
University of Freiburg · DEUniversitätsklinikum Erlangen · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEFresenius Medical Care (Germany) · DEParacelsus Medizinische Privatuniversität · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5½-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by Leishmania tropica. The patient received topical treatment with LeiProtect®, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.

Indexed as

Leishmaniasis, CutaneousLeishmania tropicaChildChloridesHumansMiddle AgedPharmaceutical PreparationsSyriaChlorideschloritePharmaceutical Preparations

Identifiers

PMID35008061
PMCPMC8922486
OpenAlexW4205170600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.