Evidence map›Paper›PMID 35007530›Full record

ArticleThe Journal of biological chemistry2022

Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation.

Shravan Morla, Hiroshi Deguchi, Jevgenia Zilberman-Rudenko, András Gruber, Owen J T McCarty, Priyanka Srivastava, David Gailani, John H Griffin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Characterization of the binding of skeletal muscle myosin to fibrin in trauma.The journal of trauma and acute care surgery · 2026
    Article
  2. Review
  3. Protein-Protein Binding Kinetics by Biolayer Interferometry.Advances in experimental medicine and biology · 2024
    Article
  4. Article
  5. Article
  6. SkM-ing information from traumatized tissue.Journal of thrombosis and haemostasis : JTH · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shravan MorlaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Hiroshi DeguchiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Jevgenia Zilberman-RudenkoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA; Departments of Biomedical Engineering and Medicine, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
András GruberDepartments of Biomedical Engineering and Medicine, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Owen J T McCartyDepartments of Biomedical Engineering and Medicine, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Priyanka SrivastavaDepartments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
David GailaniDepartments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John H GriffinDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA; Department of Medicine, University of California, San Diego, California, USA. Electronic address: jgriffin@scripps.edu.
Scripps Research Institute · USOregon Health & Science University · USVanderbilt University Medical Center · US

Funding

Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
Regulation of Protein C PathwaysR01HL142975 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H, MOSNIER, LAURENT OLIVIER · 2018 to 2025
$7.3M
Biochemistry and Pathophysiology of Factor XI and Contact ActivationR35HL140025 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAILANI, DAVID · 2018 to 2024
$5.5M
Human exomics genotyping-driven discovery and characterization of proteins related to clinical thrombosis, blood coagulation and thrombin generationR01HL133728 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL101972NHLBI NIH HHS R01 HL133728NHLBI NIH HHS R01 HL142975NHLBI NIH HHS R35 HL140025
6 · The paper itself

Abstract

Skeletal muscle myosin (SkM) has been shown to possess procoagulant activity; however, the mechanisms of this coagulation-enhancing activity involving plasma coagulation pathways and factors are incompletely understood. Here, we discovered direct interactions between immobilized SkM and coagulation factor XI (FXI) using biolayer interferometry (K

Indexed as

Blood CoagulationFactor XISkeletal Muscle MyosinsThrombinAntibodies, MonoclonalBinding SitesPrekallikreinProtein DomainsRecombinant Fusion ProteinsAntibodies, MonoclonalFactor XIPrekallikreinRecombinant Fusion ProteinsSkeletal Muscle MyosinsThrombincoagulation factorfactor XImyosinskeletal muscle myosinthrombin

Identifiers

PMID35007530
PMCPMC8856988
OpenAlexW4206778305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.