Evidence map›Paper›PMID 35007393›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd

Hui-Qi Ni, Phillippa Cooper, Shouliang Yang, Fen Wang, Neal Sach, Pranali G Bedekar, Joyann S Donaldson, Michelle Tran-Dubé, Indrawan J McAlpine, Keary M Engle

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Palladium-Catalyzed Dual CspAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Reverse Regioselective Dicarbofunctionalization via Anti-Michael-Type Addition.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Journal of the American Chemical Society · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui-Qi NiDepartment of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Phillippa CooperDepartment of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0002-8422-0945
Shouliang YangPfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.
Fen WangPfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.
Neal SachPfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.ORCID 0000-0002-9966-7459
Pranali G BedekarDepartment of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Joyann S DonaldsonPfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.ORCID 0000-0001-8873-0304
Michelle Tran-DubéPfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.
Indrawan J McAlpinePfizer Oncology Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA 92121, USA.ORCID 0000-0002-4230-4892
Keary M EngleDepartment of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0003-2767-6556

Funding

Combinatorial, Catalytic Functionalization of Alkenes and AlkynesR35GM125052 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ENGLE, KEARY MARK · 2017 to 2021
$2.9M
NIGMS NIH HHS R35 GM125052
6 · The paper itself

Abstract

In this study, we systematically evaluate different ambiphilic organohalides for their ability to participate in anti-selective carbo- or heteroannulation with non-conjugated alkenyl amides under Pd

Indexed as

AlkenesPalladiumCatalysisPyrrolidinesAlkenesPalladiumPyrrolidinesalkene functionalizationannulationdirecting groupheterocyclepalladium

Identifiers

PMID35007393
PMCPMC8923970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.