Evidence map›Paper›PMID 35007291›Full record

ArticlePloS one2022

Prevalence and factors associated with hypertension among adults with and without HIV in Western Kenya.

Jerusha Nyabiage Mogaka, Monisha Sharma, Tecla Temu, Sarah Masyuko, John Kinuthia, Alfred Osoti, Jerry Zifodya, Damalie Nakanjako, Anne Njoroge, Amos Otedo and 2 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jerusha Nyabiage MogakaDepartment of Global Health, University of Washington, Seattle, WA, United States of America.ORCID 0000-0001-9913-9034
Monisha SharmaDepartment of Global Health, University of Washington, Seattle, WA, United States of America.ORCID 0000-0002-7599-1561
Tecla TemuDepartment of Global Health, University of Washington, Seattle, WA, United States of America.
Sarah MasyukoDepartment of Global Health, University of Washington, Seattle, WA, United States of America.
John KinuthiaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Alfred OsotiDepartment of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
Jerry ZifodyaDepartment of Medicine, Section of Pulmonary, Critical Care, & Environmental Medicine, Tulane University, New Orleans, LA, United States of America.
Damalie NakanjakoDepartment of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID 0000-0002-0935-2112
Anne NjorogeDepartment of Global Health, University of Washington, Seattle, WA, United States of America.
Amos OtedoMinistry of Health, Nairobi, Kenya.
Stephanie PageDepartment of Global Health, University of Washington, Seattle, WA, United States of America.
Carey FarquharDepartment of Global Health, University of Washington, Seattle, WA, United States of America.

Funding

Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Designing an Intervention to Increase Men's Linkage to Care and Prevention after HIV Self-Testing in UgandaK01MH115789 · NIMH · UNIVERSITY OF WASHINGTON · PI SHARMA, MONISHA · 2018 to 2022
$876k
Predicting Early Cardiovascular Risk among HIV-Infected and Uninfected Kenyan AdultsR21TW010459 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY, PAGE, STEPHANIE T · 2016 to 2017
$463k
FIC NIH HHS D43 TW009580FIC NIH HHS R21 TW010459NIMH NIH HHS K01 MH115789
6 · The paper itself

Abstract

introductionThe burden of cardiovascular disease (CVD) is increasing in sub-Saharan Africa with untreated hypertension being a major contributing factor. Understanding the magnitude of the problem and risk factors associated with HIV and long-term antiretroviral therapy (ART) is critically important for designing effective programs for diagnosing and treating hypertension in Kenya.

methodsIn this cross-sectional study, we enrolled 300 persons with HIV (PWH) on long term ART (≥6 months) and 298 HIV-negative adults seeking care at the Kisumu County Hospital between September 2017 and May 2018. Hypertension was defined as blood pressure of ≥140/90mmHg or a previous hypertension diagnosis. Multivariate regression was used to assess the association between hypertension and HIV adjusting for age, sex, and known CVD risk factors.

resultsOverall prevalence of hypertension was 22%. PWH had a lower prevalence of hypertension than HIV-negative persons (16% vs 27% respectively; p<0.002). In multivariate analyses, persons with HIV were 37% less likely to have hypertension compared to HIV-negative individuals (adjusted prevalence ratio 0.63; 95% confidence interval: 0.46-0.86). Other factors that were associated with hypertension in all participants included older age >40 years, body mass index (BMI) >25 kg/m2 and low-density lipoproteins ≥130mg/dL. Among PWH, being older than 40 years and higher BMI >30 kg/m2 were associated with hypertension.

conclusionPrevalence of hypertension was high, affecting nearly one in every 4 adults, and associated with older age, higher BMI and high low-density lipoproteins. PWH on long-term ART had significantly lower prevalence of hypertension compared to HIV-negative individuals, potentially due to increased access to healthcare services and interaction with prevention messaging. Interventions to increase screening for and prevention of hypertension in the community for all adults are warranted.

Indexed as

Body Mass IndexAdultAnti-HIV AgentsBlood PressureCase-Control StudiesCross-Sectional StudiesFemaleHIVHIV InfectionsHumansHypertensionKenyaMaleMiddle AgedPrevalenceRisk FactorsAnti-HIV Agents

Identifiers

PMID35007291
PMCPMC8746744

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.