ArticlePLoS genetics2022
Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- Tryptophan catabolism reprograms immunity to prevent hemolymph bacterial dysbiosis and support molting in Spätzle-deficient Helicoverpa armigera larvae.BMC biology · 2026Article
- Toll signalling controls intestinal regeneration in Drosophila.Development (Cambridge, England) · 2026Article
- The Gut Microbiota ofMicroorganisms · 2025Review
- Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway.PLoS biology · 2025Article
- Host-Microbe Interactions in Drosophila Cancer.Advances in experimental medicine and biology · 2025Review
- Loss of the NF-κB negative regulator Pirk inBrain communications · 2025Article
- Transcriptional induction of the IMD signaling pathway and associated antibacterial activity in the digestive tract of cat fleas (Ctenocephalides felis).Parasites & vectors · 2024Article
- Developmental exposure of antibiotics shortens life span and induces teratogenicity inToxicology reports · 2024Article
- Commensal bacteria exacerbate seizure-like phenotypes in Drosophila voltage-gated sodium channel mutants.Genes, brain, and behavior · 2024Article
- Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence.Nature communications · 2024Article
- Reactive oxygen species are regulated by immune deficiency and Toll pathways in determining the host specificity of honeybee gut bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Intestinal Immune Deficiency and Juvenile Hormone Signaling Mediate a Metabolic Trade-off in AdultMetabolites · 2023Article
- The Intestinal Immune Defense System in Insects.International journal of molecular sciences · 2022Review
- Correction: Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila.PLoS genetics · 2022Article
- The Role of Microbiota inFrontiers in aging · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The gut sets the immune and metabolic parameters for the survival of commensal bacteria. We report that in Drosophila, deficiency in bacterial recognition upstream of Toll/NF-κB signalling resulted in reduced density and diversity of gut bacteria. Translational regulation factor 4E-BP, a transcriptional target of Toll/NF-κB, mediated this host-bacteriome interaction. In healthy flies, Toll activated 4E-BP, which enabled fat catabolism, which resulted in sustaining of the bacteriome. The presence of gut bacteria kept Toll signalling activity thus ensuring the feedback loop of their own preservation. When Toll activity was absent, TOR-mediated suppression of 4E-BP made fat resources inaccessible and this correlated with loss of intestinal bacterial density. This could be overcome by genetic or pharmacological inhibition of TOR, which restored bacterial density. Our results give insights into how an animal integrates immune sensing and metabolism to maintain indigenous bacteria in a healthy gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.