Evidence map›Paper›PMID 35007156›Full record

ArticleJournal of bacteriology2022

The Bacillus subtilis PriA Winged Helix Domain Is Critical for Surviving DNA Damage.

Lindsay A Matthews, Lyle A Simmons

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Comparative genomics-based insights intoApplied and environmental microbiology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Limited Role of Rhamnolipids on Cadmium Resistance for an Endogenous-Secretion Bacterium.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lindsay A MatthewsMolecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Lyle A SimmonsMolecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9600-7623
University of Michigan · US

Funding

Novel mechanisms of DNA repair and cell cycle regulation in bacteriaR35GM131772 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lyle Simmons · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM131772
6 · The paper itself

Abstract

DNA replication forks regularly encounter lesions or other impediments that result in a blockage to fork progression. PriA is one of the key proteins used by virtually all eubacteria to survive conditions that result in a blockage to replication fork movement. PriA directly binds stalled replication forks and initiates fork restart allowing for chromosomes to be fully duplicated under stressful conditions. We used a CRISPR-Cas gene editing approach to map PriA residues critical for surviving DNA damage induced by several antibiotics in B. subtilis. We find that the winged helix (WH) domain in B. subtilis PriA is critical for surviving DNA damage and participates in DNA binding. The important

Indexed as

Bacillus subtilisEscherichia coli ProteinsDNADNA DamageDNA HelicasesDNA ReplicationEscherichia coliDNADNA HelicasesEscherichia coli ProteinspriA protein, E coliBacillus subtilisDNA damagePriAreplication fork restartwinged helix domain

Identifiers

PMID35007156
PMCPMC8923177
OpenAlexW4205179233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.