Evidence map›Paper›PMID 35007126›Full record

ArticleInfection and immunity2022

ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection.

Kara A O'Neal, Leah E Latham, Enatha Ntirandekura, Camille L Foscue, Jason S Stumhofer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. T follicular helper cell development during malaria.Current opinion in immunology · 2025
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kara A O'Neal *University of Arkansas for Medical Sciencesgrid.241054.6, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.
Leah E Latham *University of Arkansas for Medical Sciencesgrid.241054.6, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.
Enatha NtirandekuraUniversity of Arkansas for Medical Sciencesgrid.241054.6, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.
Camille L FoscueUniversity of Arkansas for Medical Sciencesgrid.241054.6, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.
Jason S StumhoferUniversity of Arkansas for Medical Sciencesgrid.241054.6, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.ORCID 0000-0003-2583-0206
University of Arkansas for Medical Sciences · US

Funding

Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Regulation and function of B cells during malaria infection- ResubmissionR01AI116653 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI STUMHOFER, JASON S · 2016 to 2020
$2.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20-GM103625NCATS NIH HHS UL1 TR000039NIAID NIH HHS R01 AI116653NIGMS NIH HHS P20 GM103625
6 · The paper itself

Abstract

Inducible T cell costimulator (ICOS) plays a key role in the differentiation and maintenance of follicular helper T (Tfh) cells and, thus, germinal center (GC) formation. Previously, our laboratory showed in a Plasmodium chabaudi infection model that

Indexed as

MalariaPlasmodium yoeliiAnimalsB-LymphocytesGerminal CenterInducible T-Cell Co-Stimulator ProteinMiceMice, Inbred C57BLSpleenT-Lymphocytes, Helper-InducerIcos protein, mouseInducible T-Cell Co-Stimulator ProteinantibodyB cellsfollicular helper T cellsgerminal centerimmunologyPlasmodiumT cells

Identifiers

PMID35007126
PMCPMC8929343
OpenAlexW4220889555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.