ArticleMicrobial biotechnology2022
Rapid production of l-DOPA by Vibrio natriegens, an emerging next-generation whole-cell catalysis chassis.
Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Is faster always better? A critical assessment of Vibrio natriegens as microbial host for recombinant protein production.Bioprocess and biosystems engineering · 2026Review
- A comprehensive screening on the effect of Bacillus cereus and Vibrio natriegens bacterial consortia in cement mortar.Scientific reports · 2025Article
- Small-scale fed-batch cultivations of Vibrio natriegens: overcoming challenges for early process development.Bioprocess and biosystems engineering · 2025Article
- Low-biomass pyruvate production with engineered Vibrio natriegens is accompanied by parapyruvate formation.Microbial cell factories · 2025Article
- Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms.International journal of molecular sciences · 2025Review
- Unraveling the impact of pH, sodium concentration, and medium osmolality on Vibrio natriegens in batch processes.BMC biotechnology · 2024Article
- Ploidy inGenes · 2023Review
- Rapid, high-titer biosynthesis of melanin using the marine bacteriumFrontiers in bioengineering and biotechnology · 2023Article
- Article
- Overexpression of recombinant proteins containing non-canonical amino acids in Vibrio natriegens: p-azido-L-phenylalanine as coupling site forAmino acids · 2022Article
- Rapid production of l-DOPA by Vibrio natriegens, an emerging next-generation whole-cell catalysis chassis.Microbial biotechnology · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3, 4-Dihydroxyphenyl-l-alanine (l-DOPA) is a compound of high medical value and is considered effective as a treatment for Parkinson's disease. Currently, bioproduction of l-DOPA is mainly carried out by whole-cell catalysis mediated by recombinant Escherichia coli carrying heterogeneous tyrosine phenol lyase. Vibrio natriegens is increasingly attracting attention owing to its superiority, including extremely rapid growth and high soluble protein expression capacity. In this study, we attempt to develop an efficient whole-cell catalyst for l-DOPA production using V. natriegens as the chassis. The maximum soluble protein expression by V. natriegens was accomplished in 4 h at 37°C, which was equivalent to that achieved by E. coli in 16 h at 16°C. Furthermore, the maximum productivity reached over 10.0 g l
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