Evidence map›Paper›PMID 35006524›Full record

ArticleJournal of natural medicines2022

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro.

Mya Myat Ngwe Tun, Kazufumi Toume, Elizabeth Luvai, Khine Mya Nwe, Shusaku Mizukami, Kenji Hirayama, Katsuko Komatsu, Kouichi Morita

Abstract read
In one paragraph

Article in Journal of natural medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. The anti-coronaviral activity of singular and mixed formulation of dill essential oil (Anethum graveolens L.) and tannic acid (Quercus infectoria).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  4. Article
  5. Computational Exploration ofBioinformatics and biology insights · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review on the Diverse Biological Effects of Glabridin.Drug design, development and therapy · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Bioactive natural products in COVID-19 therapy.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mya Myat Ngwe TunDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki City, 852-8523, Japan. myamyat@tm.nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0002-8986-6307
Kazufumi ToumeSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Elizabeth LuvaiDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki City, 852-8523, Japan.
Khine Mya NweDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki City, 852-8523, Japan.
Shusaku MizukamiDepartment of Immune Regulation, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Kenji HirayamaDepartment of Immune Regulation, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Katsuko KomatsuSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Kouichi MoritaDepartment of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki City, 852-8523, Japan. moritak@nagasaki-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP20wm0125006Japan Agency for Medical Research and Development JP21wm0125006Japan Society for the Promotion of Science JP19K24679
6 · The paper itself

Abstract

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in 2019 has led to a global health crisis. Mutations of the SARS-CoV-2 genome have impeded the development of effective therapeutics and vaccines against SARS-CoV-2. Natural products are important for discovering therapeutics to treat the 2019 coronavirus disease (COVID-19). In the present study, we investigated the antiviral activity of herbal drug extracts from Polygala Root, Areca, and Quercus Bark and natural compounds derived from herbal drug such as baicalin and glabridin, with IC

Indexed as

COVID-19Pharmaceutical PreparationsAntiviral AgentsCOVID-19 VaccinesHumansSARS-CoV-2Antiviral AgentsCOVID-19 VaccinesPharmaceutical PreparationsArecaBaicalinGlabridinPolygala rootQuercus barkSARS-CoV-2

Identifiers

PMID35006524
PMCPMC8743439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.