ReviewPlant molecular biology2022
Structure, function, and evolution of plant ADP-glucose pyrophosphorylase.
Review in Plant molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Kiss and spit metabolomics highlight the role of host purine metabolism during pathogen infection.mSphere · 2026Article
- Genome-Wide Analysis of AGPase IdentifiesInternational journal of molecular sciences · 2026Article
- PHR1 mediates rapid high light responses and acclimation to high photosynthetic activity.The Plant journal : for cell and molecular biology · 2026Article
- Structure and mechanism of the heterotetrameric ADP-glucose pyrophosphorylase essential for starch synthesis in plants.Science advances · 2026Article
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- Modification of starch synthesis in food crops using CRISPR/Cas9 gene editing technology for changing climate.Stress biology · 2026Review
- DpAGPs overexpression enhanced application value of Dunaliella Parva for bioethanol production.World journal of microbiology & biotechnology · 2026Article
- Integrated Transcriptomic, Proteomic, and Metabolomic Analyses Reveal Mechanisms Underlying Day-Night Differences in Carbohydrate Metabolism between Diploid and Tetraploid Rice.Rice (New York, N.Y.) · 2025Article
- Amylopectin branch trimming and biosynthesis elucidated by the rice isoamylase ISA1-ISA2 heterocomplex.Nature communications · 2025Article
- A large-scale gene regulatory network for rice endosperm starch biosynthesis and its application in genetic improvement of rice quality.Plant biotechnology journal · 2025Article
- A Novel Allelic Variant ofCells · 2025Article
- A Suite of Pea (International journal of molecular sciences · 2025Article
- In-Silico Identification, Characterization and Expression Analysis of Genes Involved in Resistant Starch Biosynthesis in Potato (Solanum tuberosum L.) Varieties.Molecular biotechnology · 2025Article
- Sucrose synthase dynamics and its potential role in heat stress tolerance in cereals.Frontiers in plant science · 2025Review
- Expression and interaction of AGPase subunits reveal functional enzyme complexes in barley.Frontiers in plant science · 2025Article
- Transcriptome and genome-wide analysis of the mango glycosyltransferase family involved in mangiferin biosynthesis.BMC genomics · 2024Article
- ADP-glucose pyrophosphorylase gene family in soybean and implications in drought stress tolerance.Genes & genomics · 2024Article
- Engineered Chlorella vulgaris improves bioethanol production and promises prebiotic application.World journal of microbiology & biotechnology · 2024Article
- The activation ofPlant direct · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
key messageThis review outlines research performed in the last two decades on the structural, kinetic, regulatory and evolutionary aspects of ADP-glucose pyrophosphorylase, the regulatory enzyme for starch biosynthesis. ADP-glucose pyrophosphorylase (ADP-Glc PPase) catalyzes the first committed step in the pathway of glycogen and starch synthesis in bacteria and plants, respectively. Plant ADP-Glc PPase is a heterotetramer allosterically regulated by metabolites and post-translational modifications. In this review, we focus on the three-dimensional structure of the plant enzyme, the amino acids that bind the regulatory molecules, and the regions involved in transmitting the allosteric signal to the catalytic site. We provide a model for the evolution of the small and large subunits, which produce heterotetramers with distinct catalytic and regulatory properties. Additionally, we review the various post-translational modifications observed in ADP-Glc PPases from different species and tissues. Finally, we discuss the subcellular localization of the enzyme found in grain endosperm from grasses, such as maize and rice. Overall, this work brings together research performed in the last two decades to better understand the multiple mechanisms involved in the regulation of ADP-Glc PPase. The rational modification of this enzyme could improve the yield and resilience of economically important crops, which is particularly important in the current scenario of climate change and food shortage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.