Evidence map›Paper›PMID 35006468›Full record

ArticleMolecular biomedicine2021

Mibefradil alters intracellular calcium concentration by activation of phospholipase C and IP

Guilherme H Souza Bomfim, Erna Mitaishvili, Talita Ferreira Aguiar, Rodrigo S Lacruz

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Mechanosensitive Piezo1 Channels in Enamel Cells.Calcified tissue international · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. CaPhysiological reviews · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guilherme H Souza BomfimDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, 10010, USA.ORCID https://orcid.org/0000-0001-9454-7266
Erna MitaishviliDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, 10010, USA.
Talita Ferreira AguiarDepartment of Urology, New York University School of Medicine, New York, NY, 10010, USA.
Rodrigo S LacruzDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, 10010, USA. rodrigo.lacruz@nyu.edu.ORCID https://orcid.org/0000-0002-0776-6143
New York University · US

Funding

Redox and Ca2+ signaling regulation of enamel mineralizationR01DE027679 · NIDCR · NEW YORK UNIVERSITY · PI Rodrigo S. Lacruz · 2018 to 2026
$3.3M
Calcium Control of Enamel DevelopmentR01DE025639 · NIDCR · NEW YORK UNIVERSITY · PI LACRUZ, RODRIGO S. · 2016 to 2020
$2.0M
NIDCR NIH HHS DE025639NIDCR NIH HHS DE027679NIDCR NIH HHS R01 DE025639NIDCR NIH HHS R01 DE027679
6 · The paper itself

Abstract

Mibefradil is a tetralol derivative originally developed as an antagonist of T-type voltage-gated calcium (Ca

Indexed as

ALC cellsCa2+ signalingCavHEK293 cellsLS8 cellsMibefradilPLC pathway

Identifiers

PMID35006468
PMCPMC8607413
OpenAlexW3164386807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.