Evidence map›Paper›PMID 35006303›Full record

ArticlePsychopharmacology2022

Rrn3 gene knockout affects ethanol-induced locomotion in adult heterozygous zebrafish.

Fei Li, Jia Lin, Tingting Li, Jing Jian, Qi Zhang, Yinglan Zhang, Xiuyun Liu, Qiang Li

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Ribosome biogenesis in disease: new players and therapeutic targets.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fei LiTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jia LinTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Tingting LiTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jing JianTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Qi ZhangTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yinglan ZhangTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiuyun LiuTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Qiang LiTranslational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect Prevention and Control, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. liq@fudan.edu.cn.ORCID http://orcid.org/0000-0002-8388-0968
Children's Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China 81271509National Natural Science Foundation of China 81601329National Natural Science Foundation of China 81771632Natural Science Foundation of Shanghai 21ZR1410100
6 · The paper itself

Abstract

Genome-wide analysis has identified the transcription factor, RRN3 (or TIF-1A), on human chromosome 16p13.11 as a candidate gene associated with mental disorders. Both genetic and biochemical experiments have demonstrated that RRN3 plays a major role in the transcriptional regulation of ribosomal DNA and cell growth. Previous research has suggested that loss of RRN3 from mature neurons reproduces the chronic nature of neurodegenerative processes. Here, we report the first generation and characterization of rrn3 mutant zebrafish in larval and adult stages using the CRISPR/Cas9 genome editing technique. Homozygous knockout zebrafish exhibited morphological changes, such as pericardial oedema and deformed heads, and died at the larval stage of embryonic development. Behaviourally, the locomotion and shoaling behaviour of adult rrn3

Indexed as

EthanolZebrafishAnimalsFemaleGene Knockout TechniquesHumansLocomotionPregnancyTranscription FactorsEthanolTranscription FactorsBehaviourDrug sensitivityEthanolMental disordersrrn3Zebrafish

Identifiers

PMID35006303
OpenAlexW4206439044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.